载脂蛋白 M 对乳腺癌细胞生长的作用及其可能的作用机制。
The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells.
机构信息
Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, 185 Juqiang St, Changzhou, Jiangsu Province, China.
Clinical Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.
出版信息
Mol Biol Rep. 2022 Feb;49(2):1171-1179. doi: 10.1007/s11033-021-06945-2. Epub 2021 Nov 13.
BACKGROUND
To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells.
METHODS AND RESULTS
Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P < 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P < 0.05), while in MCF-7 cells, VDR levels decreased (P < 0.05).
CONCLUSIONS
ApoM can partially inhibit the growth of BC cells. VDR may play a role, but is not the main pathway.
背景
研究载脂蛋白 M（ApoM）对乳腺癌（BC）细胞生长的作用及作用机制。
方法和结果
采用生物信息学、细胞实验和动物实验验证 ApoM 对乳腺癌细胞系和体内乳腺肿瘤生长的影响。ApoM 在 BC 组织中的表达显著降低，ApoM mRNA 表达较低的患者预后较差（P<0.0001）。此外，ApoM 可部分抑制 BC 细胞的增殖、迁移和侵袭过程。在体内，ApoM-OE 组与 NC 组之间无明显差异。过表达 ApoM 可增加 MDA-MB-231 细胞中维生素 D 受体（VDR）蛋白的水平（P<0.05），而在 MCF-7 细胞中，VDR 水平降低（P<0.05）。
结论
ApoM 可部分抑制 BC 细胞的生长。VDR 可能发挥作用，但不是主要途径。
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