Chemokine Research Group, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Immunology. 2022 Feb;165(2):206-218. doi: 10.1111/imm.13430. Epub 2021 Nov 30.
The immune system plays fundamental roles in the mammary gland, shaping developmental processes and controlling inflammation during infection and cancer.Here, we reveal unanticipated heterogeneity in the myeloid cell compartment duringdevelopment of virgin, pregnant, lactating and involuting mouse mammary glands,and in milk. We investigate the functional consequences of individual and compoundchemokine receptor deficiency on cell recruitment. Diverse myeloid cell recruitmentwas also shown in models of sterile inflammation and bacterial infection.Strikingly, we have shown that inflammation and infection can alter the abundanceof terminal end buds, a key developmental structure, within the pubertal mammarygland. This previously unknown effect of inflammatory burden during puberty couldhave important implications for understanding pubertal development.
免疫系统在乳腺中起着至关重要的作用，塑造着发育过程，并在感染和癌症期间控制炎症。在这里，我们揭示了在处女、怀孕、哺乳和退化的小鼠乳腺以及乳汁中，髓样细胞区室在发育过程中的意想不到的异质性。我们研究了单个和复合趋化因子受体缺失对细胞募集的功能后果。在无菌性炎症和细菌感染模型中也显示出不同的髓样细胞募集。引人注目的是，我们已经表明，炎症和感染可以改变青春期乳腺中关键发育结构的终末芽的丰度。这种在青春期炎症负担下的先前未知的影响可能对理解青春期发育具有重要意义。
