放射性治疗在预防和管理小细胞肺癌患者脑转移中的作用：一篇综述性文章。
Radiation therapy in the prevention and management of brain metastases in patients with small cell lung cancer: a narrative review.
机构信息
Sydney West Radiation Oncology Network, Sydney, Australia; Westmead Clinical School, University of Sydney, Sydney, Australia; Westmead Institute of Medical Research, Sydney, Australia.
Department of Radiology, Westmead hospital, Sydney, Australia.
出版信息
Chin Clin Oncol. 2022 Apr;11(2):12. doi: 10.21037/cco-21-108. Epub 2021 Oct 28.
OBJECTIVE
The purpose of this narrative review is to survey the current literature and provide treatment recommendations for the management of patients with brain metastases (BMs) from small cell lung cancer (SCLC).
BACKGROUND
BMs are very common in patients with SCLC and management has changed significantly in recent years. Radiation techniques and systemic therapies have evolved and this review will highlight these recent studies and implications on clinical practice.
METHODS
This narrative review covers prophylaxis and treatment of established BMs in patients with SCLC. Studies included are based on Medline, PubMed, Google scholar searches, abstracts from conference proceedings and references from published papers.
CONCLUSIONS
Radiation therapy continue to have an important role in the prophylaxis and treatment of patients with BMs. Radiation technologies have resulted in significant reduction of toxicities and improved quality of life (QoL). There continues to be many unanswered questions and results of currently accruing trials will hopefully fill some of these gaps and refine the role of radiation therapy in the management of this condition.
目的
本叙述性综述旨在调查当前文献，并为小细胞肺癌（SCLC）脑转移（BMs）患者的治疗提供建议。
背景
BMs 在 SCLC 患者中非常常见，近年来其治疗方法发生了重大变化。放射技术和系统治疗已经发展，本综述将重点介绍这些最近的研究及其对临床实践的影响。
方法
本叙述性综述涵盖了 SCLC 患者预防和治疗已确诊 BMs 的方法。纳入的研究基于 Medline、PubMed、Google scholar 搜索、会议摘要和已发表论文的参考文献。
结论
放射治疗在预防和治疗 BMs 患者方面仍具有重要作用。放射技术已显著降低了毒性并提高了生活质量（QoL）。仍有许多悬而未决的问题，目前正在进行的试验结果有望填补其中一些空白，并完善放射治疗在该疾病管理中的作用。
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