Department of Physiotherapy and Rehabilitation, School of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey; Department of Basic Sciences, Faculty of Physical Therapy, Beni-Suef University, Beni Suef, Egypt.
Department of Physiotherapy and Rehabilitation, School of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey; Department of Physiotherapy and Rehabilitation, Faculty of Allied Medical Sciences, Arab American University, Jenin, Palestine.
J Bodyw Mov Ther. 2021 Oct;28:425-432. doi: 10.1016/j.jbmt.2021.07.012. Epub 2021 Aug 5.
The World Health Organization in March 2020 has announced that COVID-19 is a world pandemic because the number of infected cases increases rapidly. however, there are several available vaccines, their protection is limited to a certain period. Thus, the role of modalities that improve immune functions should be performed to counter COVID-19 viral load and decrease mortality rates.
To investigate the effect of aerobic exercise on immune biomarkers, disease severity, and progression in patients with COVID-19.
A randomized controlled study.
Thirty patients with COVID-19 participated in this study. Participants' age ranged from 24 to 45 years old. Participants had a mild or moderate COVID-19. Participants were assigned randomly into two groups, exercise and control groups. There were two main dependent variables including blood immune markers and severity of respiratory symptoms.
All participants performed 2 weeks of moderate-intensity aerobic exercise for 40 min/session, 3 sessions/week. The measurements were performed at baseline, and after 2-weeks.
At baseline measurements, there were non-significant differences between both groups in the Wisconsin scale total score, Leucocytes, Lymphocytes, Interleukin-6, Interleukin-10, Immunoglobulin-A, and TNF-α (P > .05). After the intervention, the Wisconsin scale (patient-oriented illness-specific quality-of-life) total score significantly decreased in the intervention group (P < .05); while, Leucocytes, Lymphocytes, and Immunoglobulin-A significantly increased in the intervention group (P < .05).
The current study indicated that 2 weeks of moderate-intensity aerobic exercise decreased the severity and progression of COVID-19 associated disorders and quality of life. Also, a 2-weeks of aerobic exercise positively affected immune function by increasing the amounts of Leucocytes, Lymphocytes, Immunoglobulin A.
世界卫生组织于 2020 年 3 月宣布 COVID-19 为全球大流行，因为感染病例数量迅速增加。然而，有几种可用的疫苗，它们的保护作用仅限于一定的时间。因此，应该发挥提高免疫功能的方法的作用，以对抗 COVID-19 病毒载量并降低死亡率。
研究有氧运动对 COVID-19 患者免疫生物标志物、疾病严重程度和进展的影响。
随机对照研究。
30 名 COVID-19 患者参加了这项研究。参与者的年龄在 24 至 45 岁之间。参与者患有轻度或中度 COVID-19。参与者被随机分为两组，即运动组和对照组。有两个主要的因变量，包括血液免疫标志物和呼吸症状的严重程度。
所有参与者均进行 2 周的中等强度有氧运动，每次 40 分钟/节，每周 3 次。在基线和 2 周后进行测量。
在基线测量时，威斯康星州量表总分、白细胞、淋巴细胞、白细胞介素-6、白细胞介素-10、免疫球蛋白-A 和 TNF-α在两组之间无显著差异（P>.05）。干预后，干预组威斯康星州量表（以患者为导向的疾病特异性生活质量）总分显著降低（P<.05）；而白细胞、淋巴细胞和免疫球蛋白-A 显著增加（P<.05）。
本研究表明，2 周的中等强度有氧运动可降低 COVID-19 相关疾病的严重程度和进展以及生活质量。此外，2 周的有氧运动通过增加白细胞、淋巴细胞和免疫球蛋白-A 的数量，对免疫功能产生积极影响。
