Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Trends Neurosci. 2022 Jan;45(1):1-2. doi: 10.1016/j.tins.2021.10.012. Epub 2021 Nov 11.
Microglia play a major role in certain neuropathological conditions. In a recent paper, Reusch et al. demonstrated how signaling pathways downstream of cannabinoid type 2 (CB) and toll-like receptors (TLRs) converge in these cells. The findings suggest that CB receptors play a permissive role in microglia activation mediated by TLRs.
小胶质细胞在某些神经病理学条件中发挥重要作用。在最近的一篇论文中，Reusch 等人展示了大麻素 2 型 (CB) 和 Toll 样受体 (TLR) 下游信号通路如何在这些细胞中汇聚。研究结果表明，CB 受体在 TLR 介导的小胶质细胞激活中发挥许可作用。
