Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
Semin Immunol. 2021 Apr;54:101523. doi: 10.1016/j.smim.2021.101523. Epub 2021 Nov 12.
Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a growth factor for its ability to promote the proliferation and differentiation in vitro of bone marrow progenitor cells into granulocytes and macrophages. Many preclinical studies, using GM-CSF deletion or depletion approaches, have demonstrated that GM-CSF has a wide range of biological functions, including the mediation of inflammation and pain, indicating that it can be a potential target in many inflammatory and autoimmune conditions. This review provides a brief overview of GM-CSF biology and signaling, and summarizes the findings from preclinical models of a range of inflammatory and autoimmune disorders and the latest clinical trials targeting GM-CSF or its receptor in these disorders.
粒细胞-巨噬细胞集落刺激因子（GM-CSF）最初被鉴定为一种生长因子，因为它能够促进骨髓祖细胞在体外增殖和分化为粒细胞和巨噬细胞。许多临床前研究使用 GM-CSF 缺失或耗竭方法表明，GM-CSF 具有广泛的生物学功能，包括炎症和疼痛的介导，表明它可以成为许多炎症和自身免疫性疾病的潜在靶点。本文简要概述了 GM-CSF 的生物学和信号转导，并总结了一系列炎症和自身免疫性疾病的临床前模型以及针对这些疾病中 GM-CSF 或其受体的最新临床试验的结果。
