Department of Neurosurgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China.
Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China.
Ann Clin Transl Neurol. 2024 Nov;11(11):2987-2997. doi: 10.1002/acn3.52210. Epub 2024 Sep 21.
To explore the relationship between 35 trace metals in scalp hair and the glioma risk as well as the potential mediating roles of 27 plasma inflammatory cytokines.
A case-control study involving 228 participants was performed in southeastern China. Trace metals in scalp hair were analyzed using inductively coupled plasma mass spectrometry, and multiplex cytokines were detected based on Luminex® technology. The least absolute shrinkage and selection operator (LASSO) regression in combination with four machine learning methods were used to select trace metals associated with gliomas. The joint exposure effect of trace metals was estimated using the generalized weighted quantile sum (gWQS) regression and quantile-based g-computation (qgcomp) algorithms.
Both LASSO regression and random forest algorithms identified five trace metals (gadolinium [Gd], lithium [Li], thulium [Tm], thorium [Th], and molybdenum [Mo]) associated with gliomas. After adjustments for potential confounders, Gd (odds ratio [OR] = 2.84, 95% confidence interval [CI]: 1.89-4.43) and Li (OR = 1.77, 95% CI: 1.04-3.02) concentrations were positively associated with glioma risk, while Tm (OR = 0.36, 95% CI: 0.17-0.73) and Th (OR = 0.45, 95% CI: 0.28-0.71) exhibited inverse associations. Both gWQS and qgcomp algorithms showed Gd contributed most to the mixture effect. Moreover, there was a significant interaction between Gd and Tm or Th on glioma risk (p < 0.05). Notably, granulocyte-macrophage colony-stimulating factor (GM-CSF) mediated the association between Gd exposure and glioma risk by 25.75%.
These findings suggest potential associations of certain trace metals, especially for Gd, with glioma risk, and may provide new insights into the mechanisms underlying from an inflammatory response perspective.
探讨头皮头发中 35 种微量元素与胶质瘤风险之间的关系，以及 27 种血浆炎症细胞因子的潜在中介作用。
在中国东南部进行了一项 228 名参与者的病例对照研究。使用电感耦合等离子体质谱法分析头皮头发中的微量元素，基于 Luminex®技术检测多种细胞因子。使用最小绝对收缩和选择算子（LASSO）回归结合四种机器学习方法来选择与胶质瘤相关的微量元素。使用广义加权量化和（gWQS）回归和基于分位数的 g 计算（qgcomp）算法来估计微量元素的联合暴露效应。
LASSO 回归和随机森林算法均鉴定出与胶质瘤相关的五种微量元素（钆[Gd]、锂[Li]、铥[Tm]、钍[Th]和钼[Mo]）。在调整潜在混杂因素后，Gd（比值比[OR] = 2.84，95%置信区间[CI]：1.89-4.43）和 Li（OR = 1.77，95% CI：1.04-3.02）浓度与胶质瘤风险呈正相关，而 Tm（OR = 0.36，95% CI：0.17-0.73）和 Th（OR = 0.45，95% CI：0.28-0.71）呈负相关。gWQS 和 qgcomp 算法均表明 Gd 对混合物效应的贡献最大。此外，Gd 和 Tm 或 Th 之间存在显著的相互作用，对胶质瘤风险有影响（p < 0.05）。值得注意的是，粒细胞-巨噬细胞集落刺激因子（GM-CSF）介导了 Gd 暴露与胶质瘤风险之间的关联，贡献率为 25.75%。
这些发现表明某些微量元素，尤其是 Gd，与胶质瘤风险之间存在潜在关联，并可能从炎症反应的角度为潜在机制提供新的见解。
