Gunes Nedim, Gül Mehmet, Dundar Serkan, Artas Gokhan, Kobat Mehmet Ali, Tekin Samet, Bozoglan Alihan, Isayev Abulfaz
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, DiyarbakirTurkey.
Department of Periodontology, Faculty of Dentistry, Harran University, SanliurfaTurkey.
J Oral Maxillofac Res. 2021 Sep 30;12(3):e2. doi: 10.5037/jomr.2021.12302. eCollection 2021 Jul-Sep.
The aim of this experimental animal study was to evaluate the effects of systemic propranolol on new bone formation in peri-implant bone defects.
Implant slots were created 4mm long and 2.5 mm wide. After the titanium implants were placed in the sockets, 2 mm defects were created in the neck of the implants. Bone grafts were placed in these defects. Then the rats were randomly divided into three equal groups: control (n = 8), propranolol dose-1 (PRP-1) (n = 8), and propranolol dose-2 (PRP-2) (n = 8) groups. In the control group, the rats received no further treatment during the eight-week experimental period after the surgery. The rats in the PRP-1 and PRP-2 groups were given 5 mg/kg and 10 mg/kg propranolol, respectively, every three days for the eight-week experimental period after the surgery. At the end of the experimental period, the rats were euthanized. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissues were used for the histological analysis.
There were no significant differences in the histological analysis results and the biochemical parameters (alkaline phosphatase, calcium, creatinine and phosphorus) of the groups (P > 0.05). Also, in the test groups, there was numerically but not statistically more new bone formation detected compared with the controls.
Within the limitations of this study, propranolol did not affect the new bone formation in peri-implant defects.
本实验动物研究旨在评估全身性普萘洛尔对种植体周围骨缺损处新骨形成的影响。
制作长4mm、宽2.5mm的种植体槽。将钛种植体植入牙槽窝后,在种植体颈部制造2mm的骨缺损。在这些缺损处植入骨移植材料。然后将大鼠随机分为三组,每组8只:对照组、普萘洛尔剂量1组(PRP-1)和普萘洛尔剂量2组(PRP-2)。对照组大鼠在术后八周的实验期内不再接受进一步治疗。PRP-1组和PRP-2组大鼠在术后八周的实验期内每三天分别给予5mg/kg和10mg/kg的普萘洛尔。实验期结束时,对大鼠实施安乐死。采集血清进行生化分析,并将种植体及周围骨组织用于组织学分析。
各组的组织学分析结果和生化参数(碱性磷酸酶、钙、肌酐和磷)无显著差异(P>0.05)。此外,在测试组中,与对照组相比,新骨形成在数值上有所增加,但无统计学意义。
在本研究的局限性范围内,普萘洛尔不影响种植体周围缺损处的新骨形成。