Ma Jinhui, Ren Yansong, Wang Bailiang, Sun Wei, Yue Debo, Wang Weiguo
Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing, 100029, P.R.China.
Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100029, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Nov 15;35(11):1486-1491. doi: 10.7507/1002-1892.202103159.
To review the research progress of subtype H vessels in the occurrence and development of osteonecrosis of the femoral head (ONFH).
The relevant domestic and foreign literature was extensively reviewed. The histological features, biological mechanism of subtype H vessels involved in promoting of osteogenesis, and the role and application of the subtype H vessels in ONFH were summarized.
The subtype H vessel is a newly discovered bone vessel, mainly distributed in metaphysis and subperiosteum, highly expressing endomucin and CD31. The subtype H vessel has a dense arrangement of Runx2 early osteoprogenitors, collagen type Ⅰα osteoblast cells, and Osterix osteoprogenitors that have the ability to induce osteogenesis and angiogenesis. Factors such as platelet-derived growth factor BB, slit guidance ligand 3, hypoxia inducible factor 1α, Notch signaling pathway, and vascular endothelial growth factor are involved in the mechanism of subtype H vessels in promoting osteogenesis.
Subtype H vessels play an important role in the regulation of angiogenesis and osteogenesis during bone tissue repair and reconstruction. The discovery of subtype H vessels provides new insights into the molecular and cellular mechanisms of osteogenesis and angiogenesis coupling. In the future, new techniques targeting the regulation of subtype H blood vessels may become a promising method for the treatment of ONFH.
综述H型血管在股骨头坏死（ONFH）发生发展中的研究进展。
广泛查阅国内外相关文献。总结H型血管的组织学特征、参与促进成骨的生物学机制以及H型血管在ONFH中的作用和应用。
H型血管是新发现的一种骨血管，主要分布于干骺端和骨膜下，高表达内黏液素和CD31。H型血管有密集排列的Runx2早期骨祖细胞、Ⅰ型胶原α成骨细胞以及具有诱导成骨和血管生成能力的Osterix骨祖细胞。血小板衍生生长因子BB、缝隙引导配体3、缺氧诱导因子1α、Notch信号通路和血管内皮生长因子等因素参与H型血管促进成骨的机制。
H型血管在骨组织修复和重建过程中的血管生成和成骨调节中起重要作用。H型血管的发现为成骨与血管生成偶联的分子和细胞机制提供了新的见解。未来，针对H型血管调节的新技术可能成为治疗ONFH的一种有前景的方法。
