Gao Jie, Liu Yanbo, Wei Jian, Jiang Linlan, Mao Jianwen, Chang Chih-Hao, Wu Duojiao
Zhongshan Hospital, Fudan University, Shanghai, China.
The Jackson Laboratory, Bar Harbor, Maine, USA.
J Leukoc Biol. 2021 Dec;110(6):1081-1090. doi: 10.1002/JLB.5MR0921-011R. Epub 2021 Nov 15.
T cells play an important role in antitumor immunity. Numbers and function of T cells are controlled by regulating the uptake and utilization of nutrients, and their antitumor activity can be promoted by targeting metabolic pathways. In this review, we highlight the relationship between metabolism and cellular function of T cells. Specifically, we emphasize the metabolic state of tumor-infiltrating T cells and review key pathways that affect the antitumor function of T cells. In the field of tumor immunotherapy, targeting T cell metabolism to enhance the immune response is a new therapeutic strategy for enhancing immunotherapy combined with traditional treatments.
T细胞在抗肿瘤免疫中发挥着重要作用。T细胞的数量和功能通过调节营养物质的摄取和利用来控制，并且可以通过靶向代谢途径来促进其抗肿瘤活性。在本综述中，我们强调了T细胞代谢与细胞功能之间的关系。具体而言，我们着重探讨肿瘤浸润性T细胞的代谢状态，并综述影响T细胞抗肿瘤功能的关键途径。在肿瘤免疫治疗领域，靶向T细胞代谢以增强免疫反应是一种将免疫治疗与传统治疗相结合的新治疗策略。
