Department of Hematology / Medical Oncology, Emory University, Atlanta, GA, United States; Winship Cancer Institute, Emory University, Atlanta, GA, United States.
Winship Cancer Institute, Emory University, Atlanta, GA, United States; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, United States.
Semin Immunol. 2020 Jun;49:101415. doi: 10.1016/j.smim.2020.101415. Epub 2020 Sep 30.
Tissue-resident memory (T) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. T- like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. T cells have also been shown to mediate anti-tumor immunity in murine models. Biology of T cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of T T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.
组织驻留记忆 (T) T 细胞是循环淋巴细胞的一个独特群体，在介导局部免疫中发挥重要作用。类似 T 细胞的细胞现在已被确定为几种人类肿瘤中肿瘤浸润淋巴细胞的一个组成部分，并且与免疫治疗的结果和反应相关。T 细胞也已被证明在小鼠模型中介导抗肿瘤免疫。T 细胞的生物学对临床癌症免疫治疗具有多种意义。在这里，我们讨论 T T 细胞生物学的新见解，并讨论它们对理解肿瘤免疫微环境异质性以及提高癌症疫苗、免疫检查点阻断和过继细胞疗法在临床中的疗效的意义。
