Cox S W, Eley B M
Department of Periodontology, King's College Hospital Dental School, London, England, U.K.
Arch Oral Biol. 1987;32(4):265-71. doi: 10.1016/0003-9969(87)90020-3.
With each material, there was only a mild early inflammatory response; particles were taken up by macrophages and giant cells. By 1.5 to 3 months, chronic granulomas had developed. With conventional amalgam, there were early changes in the intracellular material, associated with the rapid degradation of Sn-Hg particles, corresponding to the gamma 2 phase. Thereafter, intracellular particles from both types of amalgam underwent progressive degradation, producing halos of secondary material containing Ag and S. Apart from an initial loss of Cu and Sn from some high-Cu amalgam particles, there were no qualitative differences in the later changes between the two materials, although conventional amalgam particles appeared to degrade faster. With both, vast numbers of fine secondary particles containing Ag and S became widely distributed throughout the lesions and gave rise to macroscopic tattooing of the skin. Secondary material and small degrading primary particles from both types of amalgam were detected in the submandibular lymph nodes where they caused localized staining.
对于每种材料，早期仅出现轻微的炎症反应；颗粒被巨噬细胞和巨细胞摄取。到1.5至3个月时，形成了慢性肉芽肿。对于传统汞合金，细胞内物质出现早期变化，这与对应于γ2相的Sn-Hg颗粒的快速降解有关。此后，两种汞合金的细胞内颗粒都经历了渐进性降解，产生了含有Ag和S的次生物质晕圈。除了一些高铜汞合金颗粒最初损失了Cu和Sn外，两种材料后期的变化在性质上没有差异，尽管传统汞合金颗粒似乎降解得更快。两种情况下，大量含有Ag和S的细小次生颗粒广泛分布于病变各处，并导致皮肤出现肉眼可见的色素沉着。在颌下淋巴结中检测到来自两种汞合金的次生物质和正在降解的小初级颗粒，它们在那里引起局部染色。
