Boosting Chemodynamic Therapy a Synergy of Hypothermal Ablation and Oxidation Resistance Reduction.

Chemodynamic therapy (CDT), deemed as a cutting-edge antineoplastic therapeutic tactics, efficaciously suppresses tumors catalytically yielding hydroxyl radicals (OH) in tumor regions. Nevertheless, its biomedical applications are often restricted by the limited hydrogen peroxide (HO) level and upregulated antioxidant defense. Herein, a versatile nanoreactor is elaborately designed integrating CuS and MnO for -weighted magnetic resonance (MR) imaging-guided CDT, synergistically enhanced through hypothermal ablation and oxidation resistance reduction, thereby displaying splendid antitumor efficiency as well as suppression on pulmonary metastasis. The as-synthesized CuS@MnO nanoreactors afford acid-dependent Cu-based and glutathione (GSH)-activated Mn-based catalytic properties for bimodal CDT. Owing to excellent absorbance at the second near-infrared (NIR-II) window, the CuS furnishes hypo-photo-thermal therapy (PTT) against tumor growth and ameliorates the catalytic performance for thermal-enhanced CDT. Additionally, MnO significantly downregulates GSH and glutathione peroxidase 4, which synergistically boosts CDT promoting oxidative stress, simultaneously generating Mn for MR contrast improvement and activatable tumor imaging. Therefore, this study proffers a new attempt centered on the collaborative strategy integrating NIR-II hypothermal PTT and synergistically enhanced CDT for tumor eradication.