Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, P. R. China.
College of Materials Sciences and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
ACS Appl Mater Interfaces. 2021 Nov 24;13(46):54770-54782. doi: 10.1021/acsami.1c16835. Epub 2021 Nov 15.
Chemodynamic therapy (CDT), deemed as a cutting-edge antineoplastic therapeutic tactics, efficaciously suppresses tumors catalytically yielding hydroxyl radicals (OH) in tumor regions. Nevertheless, its biomedical applications are often restricted by the limited hydrogen peroxide (HO) level and upregulated antioxidant defense. Herein, a versatile nanoreactor is elaborately designed integrating CuS and MnO for -weighted magnetic resonance (MR) imaging-guided CDT, synergistically enhanced through hypothermal ablation and oxidation resistance reduction, thereby displaying splendid antitumor efficiency as well as suppression on pulmonary metastasis. The as-synthesized CuS@MnO nanoreactors afford acid-dependent Cu-based and glutathione (GSH)-activated Mn-based catalytic properties for bimodal CDT. Owing to excellent absorbance at the second near-infrared (NIR-II) window, the CuS furnishes hypo-photo-thermal therapy (PTT) against tumor growth and ameliorates the catalytic performance for thermal-enhanced CDT. Additionally, MnO significantly downregulates GSH and glutathione peroxidase 4, which synergistically boosts CDT promoting oxidative stress, simultaneously generating Mn for MR contrast improvement and activatable tumor imaging. Therefore, this study proffers a new attempt centered on the collaborative strategy integrating NIR-II hypothermal PTT and synergistically enhanced CDT for tumor eradication.
化学动力学治疗（CDT）被认为是一种前沿的抗肿瘤治疗策略，能够在肿瘤区域催化生成羟基自由基（OH）有效地抑制肿瘤。然而，其生物医学应用常常受到过氧化氢（HO）水平的限制和上调的抗氧化防御的限制。在此，设计了一种多功能纳米反应器，将 CuS 和 MnO 集成用于磁共振（MR）成像引导的 CDT，通过低热消融和氧化还原抑制协同增强，从而表现出出色的抗肿瘤效率和对肺转移的抑制作用。合成的 CuS@MnO 纳米反应器提供了酸依赖性的基于 Cu 的和谷胱甘肽（GSH）激活的基于 Mn 的双模态 CDT 催化特性。由于在近红外二区（NIR-II）窗口具有优异的吸收性，CuS 提供了针对肿瘤生长的低光热治疗（PTT），并改善了热增强 CDT 的催化性能。此外，MnO 显著下调了 GSH 和谷胱甘肽过氧化物酶 4，协同增强了 CDT，促进氧化应激，同时生成 Mn 用于 MR 对比增强和可激活的肿瘤成像。因此，本研究提供了一种新的尝试，以协同增强的 NIR-II 低热 PTT 和 CDT 为中心的协同策略，用于肿瘤消除。
