School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476, Melbourne, Victoria 3001, Australia.
Monash Biomedical Imaging, Monash University, Clayton, Victoria 3168, Australia.
J Nat Prod. 2021 Nov 26;84(11):2832-2844. doi: 10.1021/acs.jnatprod.1c00509. Epub 2021 Nov 15.
Phytochemical profiling was undertaken on the crude extracts of the bulbs, stems, and the fruits of , to determine the nature of the chemical constituents present. This represents the first study to investigate the fruits of a species of . In total, 13 new and 17 previously reported compounds were isolated and identified. The new compounds were of the phenylphenalenone-type class, with a representative of a novel structural form, named tentatively "oxabenzochromenone" (), a compound akin to an intermediate in a recently proposed phenylphenalenone metabolic network (), seven new phenylphenalenones (-), four new phenylbenzoisochromenones (-), and a new phenylbenzoisochromenone derivative (). The previously reported compounds identified were of the following structure classes: oxabenzochrysenone (, -), flavonol (, ), phenylbenzoisochromenone (, , , -), and phenylphenalenone (, ). Compounds -, -, -, , , and were subjected to antimicrobial evaluation with moderate activity observed against MRSA and slight activity against and . Compounds , -, , and were also evaluated for anthelminthic activity against larvae of the blood-feeding parasitic nematode .
对 的鳞茎、茎和果实的粗提取物进行了植物化学分析，以确定存在的化学成分的性质。这是首次对 属的果实进行研究。总共分离鉴定了 13 个新化合物和 17 个以前报道的化合物。新化合物属于苯并菲酮型类，其中一种具有新型结构形式的代表，暂命名为“氧杂苯并色烯酮”（），类似于最近提出的苯并菲酮代谢网络（）中的一种中间体的化合物，7 个新的苯并菲酮（-），4 个新的苯并异苯并色烯酮（-）和一个新的苯并异苯并色烯酮衍生物（）。鉴定出的以前报道的化合物属于以下结构类别：氧杂苯并色烯酮（，-），黄酮醇（，），苯并异苯并色烯酮（，，，-）和苯并菲酮（，）。化合物-，-，-，-，-和-进行了抗微生物评估，对耐甲氧西林金黄色葡萄球菌（MRSA）具有中等活性，对 和 具有轻微活性。化合物-，-，和-也针对寄生性血食线虫的幼虫进行了驱虫活性评估。
