Department of Medicine, Cooper University Health Care, Cooper Medical School of Rowan University, One Cooper Plaza, Camden, NJ.
Cooper Research Institute, Cooper Medical School of Rowan University, Camden, NJ.
Am J Infect Control. 2022 Apr;50(4):383-389. doi: 10.1016/j.ajic.2021.10.039. Epub 2021 Nov 13.
Approximately 80% of people with COVID-19 do not require hospitalization. Studies examining the outpatient experience have not tracked symptoms to resolution leading to unknown expected symptom duration. Our objectives were to (1) determine symptom duration among patients with COVID-19 who do not require hospitalization and (2) identify potential risk factors associated with prolonged symptom duration.
This is a retrospective cohort study conducted across an academic healthcare system including adult patients with laboratory-confirmed SARS-CoV-2 infection between March 18th and April 28th, 2020 who were not hospitalized. Symptom duration encompassed time from patient-reported symptom onset as documented in the chart until documented symptom resolution. We calculated the median symptom duration and tested if demographics, comorbidities, or reported symptoms were associated with symptom duration.
Of 294 patients meeting inclusion criteria, 178 (60.5%) had documented symptom resolution. The median [interquartile range (IQR)] symptom duration for included patients was 15 (8-24) days. No associations were found between comorbidities and symptom duration. Factors associated with prolonged symptom duration were presence vs lack of lower respiratory symptoms [median (IQR) 16.5 (10.75-33.5) vs 14.5 (7-21.75) days respectively, P < .001] and neurologic symptoms [median (IQR) 17 (9-28) vs 9.5 (4-17) days, P < .001] at disease onset.
The median symptom duration in outpatients is 15 days and over 25% of patients have symptoms longer than 21 days.
约 80%的 COVID-19 患者无需住院治疗。研究表明，对门诊患者的经验进行研究并未追踪症状的消退情况，因此无法了解预期的症状持续时间。我们的目的是：(1)确定无需住院治疗的 COVID-19 患者的症状持续时间；(2)确定与症状持续时间延长相关的潜在风险因素。
这是一项回顾性队列研究，在一个学术医疗保健系统中进行，包括 2020 年 3 月 18 日至 4 月 28 日期间实验室确诊 SARS-CoV-2 感染但无需住院的成年患者。症状持续时间是指从病历中记录的患者自述症状发作到症状完全消退的时间。我们计算了症状持续时间的中位数，并检验了人口统计学、合并症或报告的症状是否与症状持续时间相关。
在符合纳入标准的 294 名患者中，178 名（60.5%）有记录的症状缓解。纳入患者的症状持续时间中位数[四分位距（IQR）]为 15（8-24）天。合并症与症状持续时间之间未发现相关性。与症状持续时间延长相关的因素是存在或不存在下呼吸道症状[分别为 16.5（10.75-33.5）和 14.5（7-21.75）天，P <.001]和发病时的神经系统症状[分别为 17（9-28）和 9.5（4-17）天，P <.001]。
门诊患者的症状持续时间中位数为 15 天，超过 25%的患者症状持续时间超过 21 天。
