Kirtana J, Kumar Arvind, Kumar Swasthi S, Singh Anupam K, Shankar Sujay Halkur, Sharma Amrit, Kumar Amit, Kaur Ravneet, Khan Maroof A, Ranjan Piyush, Sethi Prayas, Chakravarthy Avinash, Srivastava Achal K, Wig Naveet
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Department of Medicine, Santosh Medical College, Delhi NCR, New Delhi, India.
J Family Med Prim Care. 2020 Oct 5;9(10):5360-5365. doi: 10.4103/jfmpc.jfmpc_1610_20. eCollection 2020 Oct.
Comprehensive management of mild COVID infection calls for better understanding of symptomatology in these group of patients as well as early identification and close monitoring of patients at risk, data on which is limited.
To study association between inflammatory markers and clinical presentation with progression of disease and the duration of resolution of symptoms.
This is a retrospective study that has been conducted at a designated COVID -19 medical ward at AIIMS, New Delhi.
Fifty healthcare workers and their dependents who were admitted with asymptomatic and mild COVID-19 infection were included. Their records were retrospectively reviewed, entered into a predesigned proforma and analyzed.
A total of 50 participants were included in the study of which 70% were healthcare workers. The patients were admitted with mild COVID illness out of which 22 (44%) were males. Most common symptom at presentation was fever (72%). Among patients who had mild disease versus those who progressed to moderate illness ( = 3), the patients with moderate illness were older [mean (SD): 57.33 (10.21) vs. 36.13 (14.05); = 0.014] and had a longer duration of hospital stay [17 (1.41) days vs. 11.20 (3.86) days; = 0.04]. Inflammatory markers, C-Reactive Protein (CRP) [2.46 vs. 0.20 ( = 0.024)], and Ferritin [306.15 vs. 72.53 ( = 0.023)] were higher in patients with moderate illness. There is also a significant correlation between the number of days taken for symptoms to resolve with Serum Ferritin ( = 0.007), CRP ( = 0.0256), and neutrophil lymphocyte ratio (NLR) ( = 0.044).
Acute phase reactants/Inflammatory markers serve as good indicators of time taken to resolution of symptoms in acute COVID infection. NLR is a simple and inexpensive method to provide insight into symptomatic phase. These may be utility tools for primary care physician in the management in periphery and timely decision.
对轻度新冠感染进行全面管理需要更好地了解这类患者的症状学，以及对高危患者进行早期识别和密切监测，而相关数据有限。
研究炎症标志物与临床表现之间的关联以及疾病进展和症状缓解持续时间的关系。
这是一项在新德里全印医学科学研究所指定的新冠病房进行的回顾性研究。
纳入50名因无症状和轻度新冠感染入院的医护人员及其家属。对他们的记录进行回顾性审查，录入预先设计的表格并进行分析。
该研究共纳入50名参与者，其中70%为医护人员。患者因轻度新冠疾病入院，其中22名（44%）为男性。就诊时最常见的症状是发热（72%）。在患有轻度疾病的患者与进展为中度疾病的患者（n = 3）中，中度疾病患者年龄更大[平均（标准差）：57.33（10.21）岁对36.13（14.05）岁；P = 0.014]，住院时间更长[17（1.41）天对11.20（3.86）天；P = 0.04]。中度疾病患者的炎症标志物，即C反应蛋白（CRP）[2.46对0.20（P = 0.024）]和铁蛋白[306.15对72.53（P = 0.023）]更高。症状缓解所需天数与血清铁蛋白（P = 0.007）、CRP（P = 0.0256）和中性粒细胞淋巴细胞比率（NLR）（P = 0.044）之间也存在显著相关性。
急性期反应物/炎症标志物是急性新冠感染症状缓解所需时间的良好指标。NLR是一种简单且廉价的方法，可用于深入了解症状期。这些可能是基层医疗医生在基层管理和及时决策中的实用工具。
