线粒体分子伴侣在人类健康与疾病中的作用
Mitochondrial chaperones in human health and disease.
机构信息
Department of Cell Systems & Anatomy University of Texas Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA.
Department of Cell Systems & Anatomy University of Texas Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA.
出版信息
Free Radic Biol Med. 2022 Feb 1;179:363-374. doi: 10.1016/j.freeradbiomed.2021.11.015. Epub 2021 Nov 12.
Abstract
Molecular chaperones are a family of proteins that maintain cellular protein homeostasis through non-covalent peptide folding and quality control mechanisms. The chaperone proteins found within mitochondria play significant protective roles in mitochondrial biogenesis, quality control, and stress response mechanisms. Defective mitochondrial chaperones have been implicated in aging, neurodegeneration, and cancer. In this review, we focus on the two most prominent mitochondrial chaperones: mtHsp60 and mtHsp70. These proteins demonstrate different cellular localization patterns, interact with different targets, and have different functional activities. We discuss the structure and function of these prominent mitochondrial chaperone proteins and give an update on newly discovered regulatory mechanisms and disease implications.
摘要
分子伴侣是一类通过非共价肽折叠和质量控制机制来维持细胞蛋白质内稳的蛋白质。在线粒体中发现的伴侣蛋白在线粒体生物发生、质量控制和应激反应机制中发挥着重要的保护作用。有缺陷的线粒体伴侣蛋白与衰老、神经退行性疾病和癌症有关。在这篇综述中，我们重点介绍了两种最突出的线粒体伴侣蛋白：mtHsp60 和 mtHsp70。这些蛋白质表现出不同的细胞定位模式，与不同的靶标相互作用，具有不同的功能活性。我们讨论了这些突出的线粒体伴侣蛋白的结构和功能，并更新了新发现的调节机制和疾病意义。
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