Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Biomed J. 2022 Feb;45(1):11-18. doi: 10.1016/j.bj.2021.11.004. Epub 2021 Nov 12.
Fecal microbiota transplantation (FMT) is a new and adequate route to modify the microbial ecosystem in gastrointestinal tract of the hosts. Intestinal microbiota is highly associated with human health and disease. According to the reports of human clinical trials or case series, the application of FMT ranged from Clostridiodes difficile infection (CDI), inflammatory bowel disease (IBD), irritable bowel syndrome, refractory diarrhea, diabetes mellitus, metabolic syndrome, and even neurologic diseases, including Parkinson disease, and neuropsychiatric disorder (autism spectrum disorder, ASD). Although the current allowed indication of FMT is CDI in Taiwan, more application and development are expectable in the future. There is a relative rare data available for children in application of fecal microbiota transplantation. Thus, we review previous published research inspecting FMT in children, and address particular considerations when conducting FMT in pediatric patients.
粪便微生物群移植（FMT）是一种新的、有效的途径，可以改变宿主胃肠道内的微生物生态系统。肠道微生物群与人类健康和疾病高度相关。根据人类临床试验或病例系列报告，FMT 的应用范围从艰难梭菌感染（CDI）、炎症性肠病（IBD）、肠易激综合征、难治性腹泻、糖尿病、代谢综合征，甚至神经疾病，包括帕金森病和神经精神障碍（自闭症谱系障碍，ASD）。尽管目前在台湾 FMT 的允许适应症是 CDI，但未来预计会有更多的应用和发展。在粪便微生物群移植的应用中，儿童的数据相对较少。因此，我们回顾了以前发表的关于儿童 FMT 的研究，并在对儿科患者进行 FMT 时提出了一些特殊的考虑因素。
