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链球菌蛋白G：一种在蛋白质印迹分析中检测抗人类免疫缺陷病毒蛋白抗体的灵敏工具。

Streptococcal protein G: a sensitive tool for detection of antibodies to human immunodeficiency virus proteins in Western blot analysis.

作者信息

Björck L, Blomberg J

机构信息

Department of Medical Microbiology, University of Lund, Sweden.

出版信息

Eur J Clin Microbiol. 1987 Aug;6(4):428-9. doi: 10.1007/BF02013104.

DOI:10.1007/BF02013104
PMID:3478192
Abstract

Protein G is a cell wall protein of group C and G streptococci which binds human IgG antibodies of all four subclasses with high affinity. This property of the molecule was utilized to develop a sensitive Western blot assay to detect antibodies against HIV proteins in patient sera.

摘要

蛋白G是C组和G组链球菌的一种细胞壁蛋白，它能以高亲和力结合所有四种亚类的人IgG抗体。利用该分子的这一特性开发了一种灵敏的蛋白质印迹分析法，用于检测患者血清中针对HIV蛋白的抗体。

相似文献

1
Streptococcal protein G: a sensitive tool for detection of antibodies to human immunodeficiency virus proteins in Western blot analysis.链球菌蛋白G：一种在蛋白质印迹分析中检测抗人类免疫缺陷病毒蛋白抗体的灵敏工具。
Eur J Clin Microbiol. 1987 Aug;6(4):428-9. doi: 10.1007/BF02013104.
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Patterns of antibodies to human immunodeficiency virus proteins in different subclasses of IgG.
J Infect Dis. 1987 Dec;156(6):1026-30. doi: 10.1093/infdis/156.6.1026.
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Serologic characterization of human immunodeficiency virus infection by Western blot and radioimmunoprecipitation assays.通过蛋白质印迹法和放射免疫沉淀法对人类免疫缺陷病毒感染进行血清学特征分析。
Arch Pathol Lab Med. 1987 Nov;111(11):1040-4.
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Serologic testing for human immunodeficiency virus antibodies.人类免疫缺陷病毒抗体的血清学检测。
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Status of current clinical tests for human immunodeficiency virus (HIV): applications and limitations.人类免疫缺陷病毒（HIV）当前临床试验的现状：应用与局限性
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Solid phase red cell adherence immunoassay for anti-HIV 1: a simple, rapid, and accurate method for donor screening.抗HIV固相红细胞粘附免疫测定法：一种用于献血者筛查的简单、快速且准确的方法。
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Early detection of antibodies to human immunodeficiency virus 1 by a third-generation enzyme immunoassay. A comparative study with the results of second-generation immunoassays and western blot.通过第三代酶免疫测定法早期检测人类免疫缺陷病毒1型抗体。与第二代免疫测定法和蛋白质印迹法结果的比较研究。
Ann Biol Clin (Paris). 1994;52(5):341-5.

引用本文的文献

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A Dynamic Model of pH-Induced Protein G'e Higher Order Structure Changes derived from Mass Spectrometric Analyses.基于质谱分析的pH诱导蛋白G'高级结构变化的动态模型
Anal Chem. 2016 Jan 5;88(1):890-7. doi: 10.1021/acs.analchem.5b03536. Epub 2015 Dec 9.
2
"De-novo" amino acid sequence elucidation of protein G'e by combined "top-down" and "bottom-up" mass spectrometry.通过“自上而下”和“自下而上”相结合的质谱法对G'e蛋白进行“从头”氨基酸序列解析。
J Am Soc Mass Spectrom. 2015 Mar;26(3):482-92. doi: 10.1007/s13361-014-1053-2. Epub 2015 Jan 6.

本文引用的文献

1
Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.艾滋病患者血清中与人类嗜T淋巴细胞逆转录病毒（HTLV - III）反应的抗体。
Science. 1984 May 4;224(4648):506-8. doi: 10.1126/science.6324345.
2
Purification and some properties of streptococcal protein G, a novel IgG-binding reagent.新型IgG结合试剂——链球菌蛋白G的纯化及某些特性
J Immunol. 1984 Aug;133(2):969-74.
3
Streptococcal Fc receptors. I. Isolation and partial characterization of the receptor from a group C streptococcus.
J Immunol. 1984 Jun;132(6):3091-7.
4
A surface component in group A, C, and G streptococci with non-immune reactivity for immunoglobulin G.A、C和G组链球菌中一种对免疫球蛋白G具有非免疫反应性的表面成分。
J Immunol. 1973 Nov;111(5):1401-6.
5
Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies.蛋白G：一种用于结合和检测单克隆抗体与多克隆抗体的强大工具。
J Immunol. 1985 Oct;135(4):2589-92.
6
A physicochemical study of protein G, a molecule with unique immunoglobulin G-binding properties.
J Biol Chem. 1986 Aug 5;261(22):10240-7.
7
Extraction and characterization of IgG Fc receptors from group C and group G streptococci.从C组和G组链球菌中提取和鉴定IgG Fc受体
Mol Immunol. 1986 Apr;23(4):425-31. doi: 10.1016/0161-5890(86)90140-9.