School of Population Health Sciences & Environmental Sciences, King's College London, London.
School of Population Health & Environmental Sciences, King's College London, London; National Institute for Health Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London.
Br J Gen Pract. 2022 Feb 24;72(716):e190-e198. doi: 10.3399/BJGP.2021.0325. Print 2022 Mar.
People with multimorbidity have complex healthcare needs. Some co-occurring diseases interact with each other to a larger extent than others and may have a different impact on primary care use.
To assess the association between multimorbidity clusters and primary care consultations over time.
A retrospective longitudinal (panel) study design was used. Data comprised electronic primary care health records of 826 166 patients registered at GP practices in an ethnically diverse, urban setting in London between 2005 and 2020.
Primary care consultation rates were modelled using generalised estimating equations. Key controls included the total number of long-term conditions, five multimorbidity clusters, and their interaction effects, ethnic group, and polypharmacy (proxy for disease severity). Models were also calibrated by consultation type and ethnic group.
Individuals with multimorbidity used two to three times more primary care services than those without multimorbidity (incidence rate ratio 2.30, 95% confidence interval = 2.29 to 2.32). Patients in the alcohol dependence, substance dependence, and HIV cluster (Dependence+) had the highest rate of increase in primary care consultations as additional long-term conditions accumulated, followed by the mental health cluster (anxiety and depression). Differences by ethnic group were observed, with the largest impact in the chronic liver disease and viral hepatitis cluster for individuals of Black or Asian ethnicity.
This study identified multimorbidity clusters with the highest primary care demand over time as additional long-term conditions developed, differentiating by consultation type and ethnicity. Targeting clinical practice to prevent multimorbidity progression for these groups may lessen future pressures on primary care demand by improving health outcomes.
患有多种疾病的人有复杂的医疗保健需求。一些同时发生的疾病相互作用的程度大于其他疾病,并且可能对初级保健的使用产生不同的影响。
评估随着时间的推移,多种疾病簇与初级保健就诊之间的关联。
采用回顾性纵向(面板)研究设计。数据包括 2005 年至 2020 年间在伦敦一个种族多样化的城市环境中注册的 826166 名患者的电子初级保健健康记录。
使用广义估计方程对初级保健就诊率进行建模。主要控制变量包括长期疾病总数、五个多种疾病簇及其相互作用效应、种族群体和多药治疗(疾病严重程度的代理)。还根据就诊类型和种族群体对模型进行了校准。
患有多种疾病的个体比没有多种疾病的个体使用的初级保健服务多两到三倍(发病率比 2.30,95%置信区间=2.29 至 2.32)。随着额外的长期疾病的积累,酒精依赖、物质依赖和 HIV 簇(依赖+)的患者的初级保健就诊率增加幅度最高,其次是心理健康簇(焦虑和抑郁)。观察到了种族群体之间的差异,在慢性肝病和病毒性肝炎簇中,黑人和亚洲人种的影响最大。
本研究确定了随着时间的推移,随着额外的长期疾病的发展,具有最高初级保健需求的多种疾病簇,根据就诊类型和种族群体有所不同。针对这些群体的临床实践,以预防多种疾病的进展,可能会通过改善健康结果,减轻未来对初级保健需求的压力。