State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Implant dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Int J Oral Sci. 2021 Nov 16;13(1):37. doi: 10.1038/s41368-021-00143-3.
Guided bone regeneration (GBR) uses resorbable and non-resorbable membranes as biological barriers. This study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and resorbable collagen membranes during implant placement. A total of 40 patients (65 implant sites) were enrolled and divided into two groups: resorbable membrane and digital titanium mesh groups. The alveolar bone was analyzed at two- and three-dimensional levels using cone-beam computed tomography and by reconstructing and superimposing the hard tissues at four time points: preoperatively, postoperatively, before second-stage surgery, and 1 year after loading. The use of digital titanium mesh showed less alveolar bone resorption in vertical and horizontal directions two-dimensionally before the second-stage surgery and 1 year after loading. Regarding volumetric stability, the percentage of resorption after 6 months of healing with resorbable membrane coverage reached 37.5%. However, it was only 23.4% with titanium mesh. Although postoperative bone volume was greater at all labial sites with resorbable membrane than with digital titanium mesh, after substantial bone resorption within 1 year of loading, the labial bone thickness at the upper part of implants was thinner with resorbable membrane than with digital titanium mesh. Furthermore, digital titanium meshes made according to ideal bone arch contour reduced soft tissue irritation, and the exposure rate was only 10%. Therefore, although both resorbable membrane and digital titanium mesh in GBR were able to successfully reconstruct the bone defect, digital titanium meshes were better at maintaining the hard tissue volume in the osteogenic space.
引导骨再生(GBR)使用可吸收和不可吸收的膜作为生物屏障。本研究比较了在种植体植入过程中使用基于证据的数字化钛网和可吸收胶原膜进行 GBR 时硬组织稳定性的差异。共纳入 40 名患者(65 个种植体部位),分为两组:可吸收膜组和数字化钛网组。使用锥形束 CT 对牙槽骨进行二维和三维分析,并通过在四个时间点重建和叠加硬组织来分析:术前、术后、二期手术前和加载后 1 年。与可吸收膜相比,数字化钛网在二期手术前和加载后 1 年内的牙槽骨垂直和水平方向的吸收量较少。关于体积稳定性,在使用可吸收膜覆盖的情况下,6 个月愈合后的吸收率达到 37.5%。然而,使用钛网的吸收率仅为 23.4%。虽然在使用可吸收膜的所有唇侧部位,术后骨量都比使用数字化钛网的大,但在加载后 1 年内大量骨吸收后,使用可吸收膜的唇侧骨厚度比使用数字化钛网的薄。此外,根据理想的骨弓轮廓制作的数字化钛网减少了软组织刺激,其暴露率仅为 10%。因此,尽管 GBR 中的可吸收膜和数字化钛网都能成功地重建骨缺损,但数字化钛网在维持成骨空间的硬组织体积方面更具优势。