George V T, Elston R C, Amos C I, Ward L J, Berenson G S
Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112-1393.
Genet Epidemiol. 1987;4(4):267-75. doi: 10.1002/gepi.1370040405.
A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/risk factor combinations are analysed, and at the normal 1% significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.
