Demetriades Constantinos, Nüchel Julian, Plomann Markus
Max Planck Institute for Biology of Ageing (MPI-AGE), 50931 Cologne, Germany.
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
Cell Stress. 2021 Oct 15;5(11):173-175. doi: 10.15698/cst2021.11.259. eCollection 2021 Nov.
Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity of signaling pathways, and interact with their environment by qualitatively and quantitatively modifying their intracellular, surface, and extracellular proteomes. How this delicate communication takes place is a hot topic in cell biological research, and has important implications for human disease.
细胞对应激的适应是生存、代谢、生理和疾病过程中至关重要的稳态过程。细胞通过改变信号通路的活性对应激刺激（如营养饥饿、生长因子剥夺、缺氧、能量不足等）作出反应，并通过定性和定量地改变其细胞内、表面和细胞外蛋白质组与环境相互作用。这种微妙的通讯如何发生是细胞生物学研究中的一个热门话题，并且对人类疾病具有重要意义。
