Pinho Susana C M, Faria Miguel, Casal Susana, Sobral M Madalena C, Alves Rui, Cabrita Ana R J, Fonseca António J M, Ferreira Isabel M P L V O
LAQV/REQUIMTE, Department of Chemical Sciences, Laboratory of Food Science and Hydrology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no. 228, Porto 4050-313, Portugal.
LAQV/REQUIMTE, ICBAS, School of Medicine and Biomedical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira no. 228, Porto 4050-313, Portugal.
J Agric Food Chem. 2021 Dec 1;69(47):14241-14249. doi: 10.1021/acs.jafc.1c03150. Epub 2021 Nov 16.
Research on gastric lipolysis of commercial cow's milk with different fatty acid (FA) compositions is scarce. Gastric lipase exhibits specificity for the -3 chain position of triacylglycerols, whose structure is influenced by milk FA composition. Therefore, during gastric digestion of conventional (C) vs pasture-based (P) milk, differences may occur on lipolysis, which has impact on free FA available, influencing their absorption/metabolism rate and physiological hormonal responses. Those two milk types were subjected to the INFOGEST semi-dynamic digestion model. Five gastric emptying points were analyzed for oxidative degradation of polyunsaturated fatty acids (PUFA) and individual free FA. The relative release of medium-chain FA (C8:0-C12:0) was higher than that of longer-chain FA (C14:0-C18:0), and a linear increase in markers of PUFA oxidative degradation occurred along gastric digestion. Quantitatively, C8:0, C18:2n-6, C18:3n-3, and CLA911 were higher ( < 0.001) in P milk when compared with C milk.
关于不同脂肪酸（FA）组成的商业牛乳胃脂肪分解的研究很少。胃脂肪酶对三酰甘油的-3链位置具有特异性，其结构受乳脂肪酸组成的影响。因此，在传统（C）牛奶与草饲（P）牛奶的胃消化过程中，脂肪分解可能会出现差异，这会影响游离脂肪酸的可得性，进而影响其吸收/代谢速率和生理激素反应。这两种牛奶类型都采用INFOGEST半动态消化模型进行研究。分析了五个胃排空时间点的多不饱和脂肪酸（PUFA）和单个游离脂肪酸的氧化降解情况。中链脂肪酸（C8:0 - C12:0）的相对释放量高于长链脂肪酸（C14:0 - C18:0），并且在胃消化过程中PUFA氧化降解标志物呈线性增加。定量分析表明，与C牛奶相比，P牛奶中的C8:0、C18:2n - 6、C18:3n - 3和CLA911含量更高（<0.001）。
