Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC.
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan, ROC.
Org Lett. 2021 Dec 17;23(24):9419-9424. doi: 10.1021/acs.orglett.1c03541. Epub 2021 Nov 16.
We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, -acyl compounds (esters, thioesters, amides), and -sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.
我们报告了一组新的反应，这些反应是通过简单地用烯丙基溴处理酰胺的开环反应得到的，为获得各种含氮官能团（如伯酰胺、磺胺、伯胺、-酰基化合物（酯、硫酯、酰胺）和 - 磺酰酯）提供了一个通用的平台。该方法具有潜在的工业适用性，通过批量和连续流动系统中的克级合成得到了证明。
