The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus.

OBJECTIVE

This study aims to explore the factors influencing the renal glucose threshold (RT) in patients with newly diagnosed type 2 diabetes mellitus (T2DM).

METHODS

A cross-sectional study was conducted on 1009 hospitalized patients with T2DM using stratified random sampling. Blood glucose was monitored using a dynamic blood glucose monitor to obtain the mean blood glucose (MBG), which is used to calculate the RT. The factors influencing the RT were then analyzed.

RESULTS

The mean RT in patients with newly diagnosed T2DM was 203.58 ± 55.22 mg/dl. The correlation between the RT and the various variables was analyzed, and the results demonstrated that the RT was correlated with the patient's age (r = -0.14539, P = 0.0001); MBG (r = -0.35009, P = 0.0001); renal long neck (r = 0.16762, P = 0.0001); homeostatic model assessment for insulin resistance (r = -0.38322, P = 0.0001); homeostatic model assessment for beta-cell function (r = -0.22770, P = 0.0001); and the levels of glycated hemoglobin (HbA1c; r = 0.98994, P = 0.0001), blood urea nitrogen (r = -0.11093, P = 0.0004), creatinine (r = -0.26414, P = 0.0001), uric acid (r = -0.20149, P = 0.0001), total cholesterol (r = 0.13192, P = 0.0001), low-density lipoprotein (r = 0.12466, P = 0.0001), thyroid-stimulating hormone (r = -0.06346, P = 0.0460), beta-2 microglobulin (r = -0.08884, P = 0.0056), and 24-hour urine glucose (r = 0.32115, P = 0.0001). Multiple linear stepwise regression analysis revealed that the HbA1c, 24-hour urine glucose, estimated glomerular filtration rate (eGFR), D-dimer, and body mass index (BMI) should be included in the final model, and HbA1c had the greatest impact on the RT followed in descending order by the 24-hour urine glucose, eGFR, D-dimer, and BMI (P < 0.05).

CONCLUSION

The RT increases in most patients with newly diagnosed diabetes. The risk factors for the RT are HbA1c, 24-hour urine glucose, eGFR, D-dimer, and BMI.