新诊断肥胖2型糖尿病患者血浆阿拉宁水平及其影响因素
Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients.
作者信息
Zhou Xin, Luo Mei, Zhou Sha, Cheng Zhiling, Chen Zhongpei, Yu Xiaoxia
机构信息
Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2021 Jan 27;14:379-385. doi: 10.2147/DMSO.S290072. eCollection 2021.
OBJECTIVE
To investigate the plasma alarin level in newly diagnosed obese type 2 diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism and insulin resistance.
METHODS
From October 2018 to June 2020, 239 newly diagnosed T2DM patients were collected. According to obesity, patients were divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Gender, age, body mass index (BMI), blood lipids, blood glucose, glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), plasma alarin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-β) and other clinical data were collected and analyzed.
RESULTS
BMI, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), fasting blood glucose (FPG), HbA1c, FINS, plasma alarin levels and HOMA-IR in the control group, T2DM non-obese group and T2DM obese group increased sequentially, and high-density lipoprotein-cholesterol (HDL-L) and HOMA-β decreased sequentially (P<0.05). Correlation analysis results showed that plasma alarin levels in T2DM patients were positively correlated with waistline, BMI, TC, LDL-C, FPG, HbA1c, FINS and HOMA-IR (P<0.05), and negatively correlated with HDL-C and HOMA-β (P <0.05), and the correlation coefficient of T2DM obese group was significantly higher than that of T2DM non-obese group (P<0.05). Multiple linear stepwise regression analysis showed that BMI, FPG, HbA1c, HOMA-β, and HOMA-IR were independent factors related to plasma alarin levels in T2DM non-obese and T2DM obese patients, and the correlation coefficient of the T2DM obese group was significantly higher than that of the T2DM non-obese group (P <0.05).
CONCLUSION
Plasma alarin levels increase in newly diagnosed T2DM and obese T2DM patients, which are affected by TC, BMI, FPG, HbA1c, HOMA-β and HOMA-IR, and may be involved in development of T2DM.
目的
探讨新诊断肥胖型2型糖尿病（T2DM）患者血浆阿拉宁水平及其与糖脂代谢和胰岛素抵抗的相关性。
方法
收集2018年10月至2020年6月期间239例新诊断的T2DM患者。根据是否肥胖，将患者分为T2DM肥胖组（n = 135）和T2DM非肥胖组（n = 104）。收集并分析患者的性别、年龄、体重指数（BMI）、血脂、血糖、糖化血红蛋白A1c（HbA1c）、空腹胰岛素（FINS）、血浆阿拉宁浓度、胰岛素抵抗稳态模型评估（HOMA-IR）、β细胞功能稳态模型评估（HOMA-β）等临床资料。
结果
对照组、T2DM非肥胖组和T2DM肥胖组的BMI、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、HbA1c、FINS、血浆阿拉宁水平及HOMA-IR依次升高，高密度脂蛋白胆固醇（HDL-C）及HOMA-β依次降低（P<0.05）。相关性分析结果显示，T2DM患者血浆阿拉宁水平与腰围、BMI、TC、LDL-C、FPG、HbA1c、FINS及HOMA-IR呈正相关（P<0.05），与HDL-C及HOMA-β呈负相关（P<0.05），且T2DM肥胖组的相关系数显著高于T2DM非肥胖组（P<0.05）。多元线性逐步回归分析显示，BMI、FPG、HbA1c、HOMA-β及HOMA-IR是T2DM非肥胖和T2DM肥胖患者血浆阿拉宁水平的独立相关因素，且T2DM肥胖组的相关系数显著高于T2DM非肥胖组（P<0.05）。
结论
新诊断的T2DM及肥胖T2DM患者血浆阿拉宁水平升高，受TC、BMI、FPG、HbA1c、HOMA-β及HOMA-IR影响，可能参与T2DM的发生发展。
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