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良性前列腺增生行经尿道前列腺电切术患者术后抑郁的发生率及危险因素

Incidence and Risk Factors of Post-Operative Depression in Patients Undergoing Transurethral Resection of Prostate for Benign Prostatic Hyperplasia.

作者信息

Zhu Daofang, Gao Jingjing, Dou Xianming, Peng Dangwei, Zhang Yao, Zhang Xiansheng

机构信息

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.

Department of Urology, Anhui No. 2 Provincial People's Hospital, Heifei, 230041, People's Republic of China.

出版信息

Int J Gen Med. 2021 Nov 9;14:7961-7969. doi: 10.2147/IJGM.S329817. eCollection 2021.

Abstract

BACKGROUND

Benign prostatic hyperplasia (BPH) is a frequent-occurring disease in middle-aged and elderly men. This work is a prospective study and aims at exploring the incidence of post-operative depression and the potential risk factors of depression in a cohort of patients with BPH in China.

METHODS

In this survey, 611 men who underwent transurethral resection of the prostate (TURP) were strictly selected at our institution from January 2016 to August 2019. Zung Self-rating Depression Scale was used for evaluation of depressive symptoms. Sociodemographic, clinical and other data were also collected.

RESULTS

We found that 152/611 (24.9%) patients suffered from different degree of depression at 6 months after TURP, including mild symptoms (20.9%) and moderate/severe symptoms (3.9%). A total of 421 (68.9%) patients developed post-TURP erectile dysfunction (ED). The occurrence of depression was closely associated with marital status, education level, cigarette smoking, alcohol consumption, severity of lower urinary tract symptoms (LUTS), duration of BPH, erectile function, and comorbidities (such as diabetes, dyslipidaemia and bladder stone). The risk factors related to the severity of depression included widowed or single marital status, frequent alcohol consumption, moderate or severe LUTS, longer duration (> 5 years) of BPH, ED, urinary continence, and comorbidities such as diabetes and bladder stone.

CONCLUSION

Many risk factors are related to the occurrence of depression in patients undergoing TURP. Widowed or single marital status, frequent alcohol consumption, moderate or severe LUTS, longer duration of BPH, ED, urinary incontinence and comorbidities such as diabetes and bladder stone are connected with the increase odds of moderate or severe depressive symptom.

摘要

背景

良性前列腺增生(BPH)是中老年男性的常见疾病。本研究为前瞻性研究,旨在探讨中国一组BPH患者术后抑郁症的发病率及抑郁症的潜在危险因素。

方法

在本次调查中,2016年1月至2019年8月期间,在我们机构严格筛选了611例行经尿道前列腺切除术(TURP)的男性患者。采用zung自评抑郁量表评估抑郁症状。还收集了社会人口学、临床及其他数据。

结果

我们发现,152/611(24.9%)的患者在TURP术后6个月出现不同程度的抑郁,包括轻度症状(20.9%)和中度/重度症状(3.9%)。共有421例(68.9%)患者出现TURP术后勃起功能障碍(ED)。抑郁症的发生与婚姻状况、教育程度、吸烟、饮酒、下尿路症状(LUTS)的严重程度、BPH病程、勃起功能及合并症(如糖尿病、血脂异常和膀胱结石)密切相关。与抑郁症严重程度相关的危险因素包括丧偶或单身婚姻状况、频繁饮酒、中度或重度LUTS、BPH病程较长(>5年)、ED、尿失禁以及糖尿病和膀胱结石等合并症。

结论

许多危险因素与TURP患者抑郁症的发生有关。丧偶或单身婚姻状况、频繁饮酒、中度或重度LUTS、BPH病程较长、ED、尿失禁以及糖尿病和膀胱结石等合并症与中度或重度抑郁症状的发生几率增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b67/8590608/6226b60d577d/IJGM-14-7961-g0001.jpg

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