共病抑郁症和危险饮酒在线干预的随机对照试验：主要结局结果

Randomized controlled trial of online interventions for co-occurring depression and hazardous alcohol consumption: Primary outcome results.

作者信息

Cunningham John A, Godinho Alexandra, Hendershot Christian S, Kay-Lambkin Frances, Neighbors Clayton, Griffiths Kathleen M, Schell Christina

机构信息

National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom.

Centre for Addiction and Mental Health, Toronto, Canada.

出版信息

Internet Interv. 2021 Nov 2;26:100477. doi: 10.1016/j.invent.2021.100477. eCollection 2021 Dec.

DOI:10.1016/j.invent.2021.100477

PMID:34786350

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8579144/

Abstract

BACKGROUND AND AIMS

The current trial tested the benefits of offering a brief online intervention for hazardous alcohol consumption along with one for depression among people experiencing both conditions.

METHODS

Online advertisements were used to recruit people with persistent low mood. Those who also had current hazardous alcohol consumption were identified and invited to take part in the trial (those not eligible were offered access to the online depression intervention). Participants were randomized to an established intervention for depression (MoodGYM; M-only) or to receive MoodGYM plus a brief personalized feedback intervention for hazardous drinking (Check Your Drinking; M + CYD). Participants were followed-up at three and six months.

RESULTS

While levels of depression symptoms ( < .001) and hazardous alcohol consumption ( < .001) reduced in both the M-only and the M + CYD groups, there was no difference between groups on drinking ( = .374) or depression outcomes ( = .752). Further, participants who were provided both interventions logged into the intervention website less often ( = 4.1, = 3.9) compared to participants only offered the depression intervention ( = 4.9, = 5.2), (986) = 2.47, = .014. However, there was no significant difference ( > .05) in the number of MoodGYM modules completed between the two groups.

DISCUSSION AND CONCLUSION

The current trial found no benefit to providing a brief online intervention for hazardous alcohol consumption alongside one for depression among people experiencing these co-occurring disorders. Further, the finding that adding an online intervention for drinking to one for depression led to a small reduction in the number of times the interventions were accessed implies the need for caution when deciding how best to provide online help to those with co-occurring depression and hazardous alcohol consumption.Trial Registration: ClinicalTrials.govNCT03421080.

摘要

背景与目的

当前试验检验了针对同时患有危险饮酒和抑郁症的人群，提供简短的在线危险饮酒干预以及抑郁症干预的益处。

方法

通过在线广告招募持续情绪低落的人群。识别出同时存在当前危险饮酒情况的人并邀请其参加试验（不符合条件的人可获得在线抑郁症干预）。参与者被随机分配到既定的抑郁症干预组（情绪健身房；仅M组）或接受情绪健身房干预加针对危险饮酒的简短个性化反馈干预（检查你的饮酒情况；M + CYD组）。在三个月和六个月时对参与者进行随访。

结果

仅M组和M + CYD组的抑郁症状水平（<.001）和危险饮酒量（<.001）均有所降低，但两组在饮酒结果（= 0.374）或抑郁结局（= 0.752）方面没有差异。此外，与仅接受抑郁症干预的参与者（= 4.9，= 5.2）相比，同时接受两种干预的参与者登录干预网站的频率更低（= 4.1，= 3.9），（986）= 2.47，= 0.014。然而，两组在完成的情绪健身房模块数量上没有显著差异（> 0.05）。

讨论与结论

当前试验发现，对于同时患有这些共病的人群，在提供抑郁症干预的同时提供简短的在线危险饮酒干预并无益处。此外，在抑郁症干预中增加饮酒在线干预导致干预访问次数略有减少这一发现表明，在决定如何最好地为同时患有抑郁症和危险饮酒的人提供在线帮助时需要谨慎。试验注册：ClinicalTrials.govNCT03421080。