Park Hong-Kyun, Chu Min Kyung, Oh Sun-Young, Moon Heui-Soo, Song Tae-Jin, Lee Mi Ji, Kang Jin-Ju, Hong Yooha, Cho Soo-Jin
Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Cephalalgia. 2022 May;42(6):455-465. doi: 10.1177/03331024211057184. Epub 2021 Nov 17.
Characteristics, disabilities, and optimal management of medication overuse headache remain uncertain. This study aimed to elucidate the clinical characteristics of patients with medication overuse headache enrolled in a medication overuse headache registry in Korea.
The Registry for Load and Management of MEdicAtion OveruSE Headache (RELEASE), a cross-sectional prospective observational study including seven referral headache centers in Korea, started enrolling adult patients with medication overuse headache in April 2020. Data included information on headache characteristics, burden on daily function, depression, anxiety, history of acute and preventive medications, and treatment strategies.
A total of 229 patients (85.6% females; mean age, 45.5 ± 13.5 years) were enrolled by June 2021. The average durations of chronic headaches and medication overuse were 6.5 and 4.3 years, respectively. In the past month before enrollment, patients had headaches for 25 days and severe headaches for 12 days, and used acute medications for 20 days. Patients were disabled in 66.8 days in the past 3 months and had moderate/severe depression and anxiety in 56% and 35%, respectively. The proportion of patients on preventive treatments increased from 38% to 93% during the study period.
RELEASE study reflects the current management status and opportunities to improve the quality of care in patients with medication overuse headache.
药物过度使用性头痛的特征、残疾情况及最佳管理方法仍不明确。本研究旨在阐明韩国药物过度使用性头痛登记处登记的药物过度使用性头痛患者的临床特征。
药物过度使用性头痛负荷与管理登记研究（RELEASE）是一项横断面前瞻性观察性研究，纳入了韩国的7个转诊头痛中心，于2020年4月开始招募药物过度使用性头痛的成年患者。数据包括头痛特征、日常功能负担、抑郁、焦虑、急性和预防性药物治疗史以及治疗策略等信息。
截至2021年6月，共招募了229例患者（女性占85.6%；平均年龄45.5±13.5岁）。慢性头痛和药物过度使用的平均持续时间分别为6.5年和4.3年。在入组前的过去一个月中，患者头痛25天，严重头痛12天，使用急性药物20天。在过去3个月中，患者有66.8天功能受限，分别有56%和35%的患者存在中度/重度抑郁和焦虑。在研究期间，接受预防性治疗的患者比例从38%增加到93%。
RELEASE研究反映了药物过度使用性头痛患者当前的管理状况以及改善护理质量的机会。
