Murugan Chandnee, Kailasam Vignesh
Sri Ramachandra Faculty of Dental Sciences (SRIHER), Chennai, TN, India.
Cleft Palate Craniofac J. 2023 Jan;60(1):39-54. doi: 10.1177/10556656211053545. Epub 2021 Nov 17.
Diverse findings have been reported for the cranial base angle (CBA) in patients with CLP (cleft lip and palate) and non-CLP controls. The aim of this study is to assess and evaluate the CBA in patients with CLP and non-CLP controls. Data from PubMed, OVID Technologies, Inc., Cochrane, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scopus, Web of Science, and EMBASE for Excerpta Medica dataBASE (EMBASE) with relevant terms was extracted until December 31, 2020. Inclusion criteria were data of patients with non-syndromic unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP). In the case of UCLP and BCLP, patients with craniofacial syndromes were excluded. The study proposal was registered with PROSPERO (Registration number: CRD42021228632). Fifteen studies with a total of 2032 participants were included for the systematic review and 14 studies with a total of 1972 participants were included for the meta-analysis. The risk of bias was assessed using the Modified Newcastle Ottawa scale under seven domains by two authors. Thirteen studies were graded as "good" and two as "satisfactory." The CBA in patients with CLP were greater than the non CLP Class I controls in six of the 15 studies. CBA was greater in patients with CLP than non-CLP controls by 1.21° (95% CI of 0.19-2.22). Meta-analysis reported considerable heterogeneity (I = 86%). Anterior (ACB) and posterior cranial base (PCB) lengths were shorter in patients with CLP than in the non-cleft Class I controls by 2.14 mm (95% CI of 0.99-3.30) and 2.06 mm (95% CI of 1.52-2.60), respectively. Most studies were graded as good. Patients with CLP had greater CBA and shorter ACB and PCB lengths when compared to non-CLP controls.
关于唇腭裂（CLP）患者和非唇腭裂对照者的颅底角（CBA），已有多种研究结果报道。本研究旨在评估和评价唇腭裂患者及非唇腭裂对照者的颅底角。从PubMed、OVID Technologies公司、Cochrane、拉丁美洲及加勒比地区卫生科学文献数据库（LILACS）、Scopus、科学网和Excerpta Medica数据库（EMBASE）中提取截至2020年12月31日的相关数据，检索词为相关术语。纳入标准为非综合征性单侧唇腭裂（UCLP）和双侧唇腭裂（BCLP）患者的数据。对于UCLP和BCLP患者，排除患有颅面综合征的患者。该研究方案已在国际前瞻性系统评价注册库（PROSPERO）注册（注册号：CRD42021228632）。纳入15项研究，共2032名参与者进行系统评价，纳入14项研究，共1972名参与者进行荟萃分析。由两位作者使用改良的纽卡斯尔渥太华量表在七个领域评估偏倚风险。13项研究被评为“良好”，两项被评为“满意”。在15项研究中的6项中，唇腭裂患者的颅底角大于非唇腭裂I类对照者。唇腭裂患者的颅底角比非唇腭裂对照者大1.21°（95%置信区间为0.19 - 2.22）。荟萃分析显示存在相当大的异质性（I² = 86%）。唇腭裂患者的前颅底（ACB）和后颅底（PCB）长度分别比非腭裂I类对照者短2.14 mm（95%置信区间为0.99 - 3.30）和2.06 mm（95%置信区间为1.52 - 2.60）。大多数研究被评为良好。与非唇腭裂对照者相比，唇腭裂患者的颅底角更大，前颅底和后颅底长度更短。
