SUMOylation 波锚定基因组。

A SUMOylation wave to anchor the genome.

机构信息

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburg, UK.

出版信息

J Cell Biol. 2021 Dec 6;220(12). doi: 10.1083/jcb.202110031. Epub 2021 Nov 16.

DOI:10.1083/jcb.202110031

PMID:34787674

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8600798/

Abstract

Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202103036) identify a phosphorylation and SUMOylation-dependent cascade that links chromatin to the nuclear membrane during late mitosis.

摘要

有丝分裂期间，染色质与核膜的连接丢失，以促进染色体分离。然而，这些连接如何重新建立以确保有丝分裂间期基因组的正常功能尚不清楚。Ptak 等人（2021 年，《细胞生物学杂志》，https://doi.org/10.1083/jcb.202103036）确定了一个在有丝分裂后期将染色质与核膜连接的磷酸化和 SUMO 化依赖级联反应。