Cambridge Institute for Medical Research, University of Cambridge , Cambridge, UK.
J Cell Biol. 2023 Aug 7;222(8). doi: 10.1083/jcb.202306126. Epub 2023 Jul 13.
Eukaryotic cell division involves the segregation of chromosomes between two daughter cells and must be coordinated with extensive rearrangement of their nuclear envelopes. In this issue, Saik et al. (2023 J. Cell Biol. https://doi.org/10.1083/jcb.202208137) show that a SUMOylation cascade at the inner nuclear membrane elevates the levels of phosphatidic acid, a key phospholipid precursor, to support the need for nuclear membrane expansion during mitosis.
真核细胞分裂涉及染色体在两个子细胞之间的分离，必须与核膜的广泛重排相协调。在本期中，Saik 等人（2023 J. Cell Biol. https://doi.org/10.1083/jcb.202208137）表明，核膜内层的 SUMOylation 级联反应会提高磷脂酸（一种关键的磷脂前体）的水平，以支持有丝分裂期间核膜扩张的需要。
