Effects and side-effects of bromperidol in comparison with other antipsychotic drugs.

In 1975 we performed an open trial with bromperidol in 25 hospitalized schizophrenic patients. Effects and side-effects were registered by means of the AMP system. Patients were treated up to 30 days and the dosage of bromperidol was increased depending on effects and side-effects up to 5 mg per day. Bromperidol showed a good effect on productive schizophrenic symtpoms and caused a significant reduction of accompanying depressive symptoms. Data of this open trial were compared with data of two open trials with clozapine and haloperidol which were performed using the same methods. We compared the three open trials and found similar effects on psychotic symptomatology, but a different severity of extrapyramidal side-effects. A double-blind comparison between bromperidol and perphenazine in 40 schizophrenic patients showed a strong antipsychotic efficacy of bromperidol and an earlier onset of its effects.