Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Lasers Surg Med. 2022 Jan;54(1):46-53. doi: 10.1002/lsm.23494. Epub 2021 Nov 17.
Non-ablative fractional laser is an effective modality for the treatment of periorbital wrinkling, one of the earliest signs of skin aging. Thermo-mechanical fractional injury (TMFI) therapy (Tixel®, Novoxel®, Israel) is an innovative technology that is now being used for facial skin rejuvenation. Our study compares the clinical results, side effects, and downtime profile between TMFI treatment and non-ablative fractional 1565 nm laser (ResurFX®, Lumenis, Israel).
This was a prospective study of 68 patients (64 women, 4 men) with skin types I-VI in two medical centers (34 from Israel, 34 from the USA) that were randomized to receive either TMFI or NAFL treatment for periorbital wrinkling. Patients received 3-5 treatments, 3-5 weeks apart. Six months after the last treatment, the change in Fitzpatrick Wrinkling Classification System (FWCS) was calculated by three non-involved physicians and compared to pretreatment results. Side effects and downtime profiles were assessed in each group (including VAS pain assessment, time required to refrain from work and social activity, and time required for the resolution of redness, edema, and crusts.) RESULTS: A moderate improvement in periorbital wrinkling was demonstrated in both groups, with an average improvement of 1.6 ± 0.6 in FWCS in the TMFI group and an average improvement of 1.7 ± 0.8 in the NAFL group (p < 0.001). Postprocedural VAS score was 5.86 ± 2.3 in the NAFL group and 4.01 ± 2.6 in the Tixel® group. Approximately 80% of subjects returned to both work and social activities two days postprocedure. Crusts were reported by 52% of patients in the TMFI group, compared to 16% of patients in the NAFL group more than 48 hours postprocedure (p < 0.05). There were no statistically significant differences in the other parameters between the two groups.
TMFI is an effective and safe modality for the treatment of periorbital wrinkling, with comparable results to the 1565 nm NAFL.
非剥脱性点阵激光是治疗眶周皱纹的有效方法之一，眶周皱纹是皮肤衰老的最早迹象之一。热机械性点阵损伤（TMFI）疗法（Tixel ® ，Novoxel ® ，以色列）是一种创新技术，现正用于面部皮肤年轻化。我们的研究比较了 TMFI 治疗与非剥脱性 1565nm 激光（ResurFX ® ，Lumenis ，以色列）治疗眶周皱纹的临床效果、副作用和停机时间。
这是在两个医疗中心（以色列 34 例，美国 34 例）进行的前瞻性研究，共 68 例 I-VI 型皮肤的患者（64 名女性，4 名男性）被随机分为 TMFI 或 NAFL 治疗眶周皱纹。患者每 3-5 周接受 3-5 次治疗。末次治疗后 6 个月，由 3 名非参与医生计算 Fitzpatrick 皱纹分类系统（FWCS）的变化，并与治疗前结果进行比较。评估了每组的副作用和停机时间（包括 VAS 疼痛评估、避免工作和社交活动所需的时间，以及红斑、水肿和结痂消退所需的时间。）
两组患者的眶周皱纹均有中度改善，TMFI 组 FWCS 平均改善 1.6±0.6，NAFL 组平均改善 1.7±0.8（p<0.001）。NAFL 组术后 VAS 评分为 5.86±2.3，Tixel ® 组为 4.01±2.6。术后约 80%的患者可在两天内恢复工作和社交活动。TMFI 组有 52%的患者出现结痂，而 NAFL 组有 16%的患者在术后 48 小时以上出现结痂（p<0.05）。两组其他参数无统计学差异。
TMFI 是治疗眶周皱纹的有效、安全方法，与 1565nm NAFL 结果相当。
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