Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, Telangana 502285, India.
Department of Pharmacology, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana 500028, India.
ACS Appl Mater Interfaces. 2021 Dec 1;13(47):55862-55878. doi: 10.1021/acsami.1c17054. Epub 2021 Nov 17.
Metastasis is one of the predisposing factors for cancer-related mortalities worldwide. Patients with advanced cancers (stage IV) receive palliative care with minimal possibility of achieving complete remission. Antibody-based therapeutic modalities are capable of targeting tumors that are confined to a particular location but are ineffective in targeting distant secondary tumors. In the current study, we have developed a smart nano-transforming hydrogel (NTG) that transforms to polymeric nanoparticles (PA NPs) of 100-150 nm when injected subcutaneously. These nanoparticles targeted the primary and secondary metastatic tumors for up to ∼5 and ∼3 days, respectively. The -formed PA NPs also demonstrated a pH-responsive drug release resulting in about ∼80% release within 100 h at 5.8 pH. When tested substantial inhibition of lung metastases was observed compared to chemotherapy, thus demonstrating the efficiency of nanotransforming hydrogels in targeting and inhibiting primary and secondary metastatic tumors.
转移是全球癌症相关死亡的一个促成因素。晚期癌症（IV 期）患者接受姑息治疗，完全缓解的可能性极小。基于抗体的治疗方法能够针对局限于特定部位的肿瘤，但对远处继发性肿瘤无效。在本研究中，我们开发了一种智能纳米转化水凝胶（NTG），当皮下注射时，它会转化为 100-150nm 的聚合物纳米颗粒（PA NPs）。这些纳米颗粒分别靶向原发性和继发性转移性肿瘤，时间长达约 5 天和 3 天。形成的 PA NPs 还表现出 pH 响应性药物释放，在 5.8 pH 下，约 100 h 内释放约 80%。与化疗相比，当进行测试时，观察到肺转移的显著抑制，从而证明了纳米转化水凝胶在靶向和抑制原发性和继发性转移性肿瘤方面的效率。
