Department of Health Promotion and Behavior, College of Public Health, University of Georgia, Athens, Georgia, USA.
Department of Health Policy and Management, College of Public Health, University of Georgia, Athens, Georgia, USA.
J Am Coll Health. 2023 Dec;71(9):2859-2868. doi: 10.1080/07448481.2021.2002336. Epub 2021 Nov 17.
We examine role of ACEs and pathways to risk of opioid misuse among young adults. Participants and A cross-sectional survey of validated measures of ACEs, risk of opioid misuse, and health conditions with a sample of 1,402 students from a large public university followed by multivariate logistic regression and pathway analysis. Majority (61%) of participants reported at least one ACE. A dose-response relationship between numbers of ACEs with risk for opioid misuse was present. Compared to participants with no ACEs, participants with ≥4 ACEs and 0-3 ACEs were 2.93 (95% CI: 1.95, 4.39; < 0.001) and 1.96 (95% CI: 1.46, 2.65; < 0.001) times more likely to be at risk for opioid misuse, respectively. Having at least one existing or past health condition significantly mediated the association. Our findings suggest need to include assessment of ACEs as a screening criterion for opioid prescription and administration among college-aged individuals.
我们研究了 ACE 对年轻人阿片类药物滥用风险的作用及其途径。参与者为来自一所大型公立大学的 1402 名学生，采用横断面调查，使用经过验证的 ACE 测量方法、阿片类药物滥用风险和健康状况的测量方法，然后进行多变量逻辑回归和途径分析。大多数（61%）参与者报告至少有一种 ACE。ACE 数量与阿片类药物滥用风险之间存在剂量反应关系。与没有 ACE 的参与者相比，有≥4 种 ACE 和 0-3 种 ACE 的参与者发生阿片类药物滥用风险的几率分别高出 2.93 倍（95%CI：1.95，4.39； < 0.001）和 1.96 倍（95%CI：1.46，2.65； < 0.001）。至少有一种现有的或过去的健康状况显著中介了这种关联。我们的研究结果表明，需要将 ACE 的评估作为对大学生群体开具和管理阿片类药物处方的筛选标准。
