Department of Applied Health Science, Indiana University, 1025 E. 7th St., Suite 116, Bloomington, IN, 47405, USA.
Department of Psychology, Arizona State University, Tempe, USA.
Sci Rep. 2021 Nov 17;11(1):22425. doi: 10.1038/s41598-021-01923-x.
Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of genetic variants identified from EA samples in other racial/ethnic populations, leading to inconclusive findings about genetic effects on alcohol use. The current study examined how genetic influences on alcohol use varied by age across a 15 year period within a diverse ethnic/racial sample of adolescents. Using a multi-ethnic approach, polygenic risk scores were created for African American (AA, n = 192) and EA samples (n = 271) based on racially/ethnically aligned genome wide association studies. Age-varying associations between polygenic scores and alcohol use were examined from age 16 to 30 using time-varying effect models separately for AA and EA samples. Polygenic risk for alcohol use was found to be associated with alcohol use from age 22-27 in the AA sample and from age 24.50 to 29 in the EA sample. Results are discussed relative to the intersection of alcohol use and developmental genetic effects in diverse populations.
遗传对酒精使用的影响可能随时间而变化，但通常使用纵向模型来预测单一时间点的远端结果进行检查。这些研究绝大多数主要使用白种人或欧洲裔美国人（EA）样本来检验遗传效应，或者在其他种族/民族群体中检验从 EA 样本中确定的遗传变异的病因，从而导致对酒精使用的遗传效应的不确定发现。本研究在一个多样化的青少年种族/民族样本中，在 15 年的时间内，通过多民族方法，根据种族/民族一致的全基因组关联研究，为非裔美国人（AA，n=192）和 EA 样本（n=271）创建了多基因风险评分。分别使用 AA 和 EA 样本的时变效应模型，从 16 岁到 30 岁，检查了多基因评分与酒精使用之间的时变关联。在 AA 样本中，从 22 岁到 27 岁，在 EA 样本中，从 24.50 岁到 29 岁，发现多基因风险与酒精使用有关。结果与不同人群中酒精使用和发育遗传效应的交集有关。
