Department of Applied Health Science, Indiana University, Bloomington, IN, USA.
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Dev Psychopathol. 2024 Feb;36(1):82-91. doi: 10.1017/S0954579422000980. Epub 2022 Aug 19.
Externalizing behavior in early adolescence is associated with alcohol use in adolescence and early adulthood and these behaviors often emerge as part of a developmental sequence. This pattern can be the result of heterotypic continuity, in which different behaviors emerge over time based on an underlying shared etiology. In particular, there is largely a shared genetic etiology underlying externalizing and substance use behaviors. We examined whether polygenic risk for alcohol use disorder predicted (1) externalizing behavior in early adolescence and alcohol use in adolescence in the Early Steps Multisite sample and (2) externalizing behavior in adolescence and alcohol use in early adulthood in the Project Alliance 1 (PAL1) sample. We examined associations separately for African Americans and European Americans. When examining European Americans in the Early Steps sample, greater polygenic risk was associated with externalizing behavior in early adolescence. In European Americans in PAL1, we found greater polygenic risk was associated with alcohol use in early adulthood. Effects were largely absent in African Americans in both samples. Results imply that genetic predisposition for alcohol use disorder may increase risk for externalizing and alcohol use as these behaviors emerge developmentally.
青少年早期的外化行为与青少年和成年早期的酒精使用有关，这些行为通常是发展序列的一部分。这种模式可能是异型连续性的结果，即不同的行为随着时间的推移基于潜在的共同病因而出现。特别是，外化行为和物质使用行为的背后主要有一个共同的遗传病因。我们研究了酒精使用障碍的多基因风险是否可以预测：(1)早期步骤多地点样本中青少年早期的外化行为和青少年时期的酒精使用；以及(2)项目联盟 1 (PAL1) 样本中青少年时期的外化行为和成年早期的酒精使用。我们分别为非裔美国人和欧洲裔美国人检查了关联。在早期步骤样本中的欧洲裔美国人中，更大的多基因风险与青少年早期的外化行为有关。在 PAL1 中的欧洲裔美国人中，我们发现更大的多基因风险与成年早期的酒精使用有关。在这两个样本中的非裔美国人中，影响基本上都不存在。研究结果表明，酒精使用障碍的遗传易感性可能会增加这些行为在发展过程中出现时的外化和酒精使用的风险。
