School of Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Center of Research and Development, ACRO Biomedical Co., Ltd. Kaohsiung, Taiwan.
Int J Med Sci. 2021 Sep 13;18(16):3684-3691. doi: 10.7150/ijms.64359. eCollection 2021.
Orbital floor fractures subsequently lead to consequences such as diplopia and enophthalmos. The graft materials used in orbital floor fractures varied from autografts to alloplastic grafts, which possess certain limitations. In the present study, a novel porcine bone matrix decellularized by supercritical CO2 (scCO2), ABCcolla® Collagen Bone Graft, was used for the reconstruction of the orbital framework. The study was approved by the institutional review board (IRB) of Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH). Ten cases underwent orbital floor reconstruction in KMUH in 2019. The orbital defects were fixed by the implantation of the ABCcolla® Collagen Bone Graft. Nine out of ten cases used 1 piece of customized ABCcolla® Collagen Bone Graft in each defect. The other case used 2 pieces of customized ABCcolla® Collagen Bone Graft in one defect area due to the curved outline of the defect. In the outpatient clinic, all 10 cases showed improvement of enophthalmos on CT (computerized tomography) at week 8 follow-up. No replacement of implants was needed during follow-ups. To conclude, ABCcolla® Collagen Bone Graft proved to be safe and effective in the reconstruction of the orbital floor with high accessibility, high stability, good biocompatibility, low infection rate and low complication rate.
眶底骨折随后会导致复视和眼球内陷等后果。眶底骨折中使用的移植物材料从自体移植物到同种异体移植物都有一定的局限性。在本研究中，一种新型的猪骨基质经超临界 CO2（scCO2）脱细胞处理，即 ABCcolla®胶原骨移植物，用于眼眶框架的重建。该研究得到了高雄医学大学附设中和纪念医院（KMUH）机构审查委员会（IRB）的批准。2019 年，在 KMUH 有 10 例患者接受了眶底重建。通过植入 ABCcolla®胶原骨移植物固定眶底缺损。10 例中有 9 例在每个缺损部位使用 1 块定制的 ABCcolla®胶原骨移植物，另 1 例由于缺损轮廓弯曲，在一个缺损区域使用了 2 块定制的 ABCcolla®胶原骨移植物。在门诊，所有 10 例患者在第 8 周随访时 CT（计算机断层扫描）显示眼球内陷改善。随访期间无需更换植入物。总之，ABCcolla®胶原骨移植物在眶底重建中具有高可及性、高稳定性、良好的生物相容性、低感染率和低并发症率，证明是安全有效的。
