Johnston D E, Kaplan M M, Miller K B, Connors C M, Milford E L
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.
Am J Gastroenterol. 1987 Nov;82(11):1127-9.
HLA-A, -B, and -DR antigens were examined in 71 patients with primary biliary cirrhosis (PBC) enrolled in a randomized, double-blind trial of colchicine versus placebo. All patients had typical laboratory and histological features of PBC, except that six had a negative test for antimitochondrial antibody. Frequencies of these antigens were compared with the international Caucasian panel of the Eighth International Workshop and with a local Caucasian panel. Antigen frequencies were compared using the chi 2 test, with a correction for the number of antigens tested. The PBC patients had a significant excess of DR4 (29 of 70 typed, or 41.1%) compared to the international (804 of 3811, or 21.1%, corrected p value less than 0.05) but not the local panel (47 or 129, or 36.4%). Of PBC patients, 52.9% had only one DR antigen identified, compared to 67.5% for the international panel and 49.6% for the local panel. In past studies, the HLA antigen most strongly correlated with PBC was DR8, but this was not included in our panel of antisera. However, no significant relationship between HLA and PBC was found among the antigens screened.
在一项秋水仙碱与安慰剂的随机双盲试验中，对71例原发性胆汁性肝硬化（PBC）患者的HLA - A、- B和 - DR抗原进行了检测。所有患者均具有PBC典型的实验室和组织学特征，不过有6例抗线粒体抗体检测呈阴性。将这些抗原的频率与第八届国际研讨会的国际白种人样本以及当地白种人样本进行了比较。使用卡方检验比较抗原频率，并对检测的抗原数量进行了校正。与国际样本（3811例中有804例，即21.1%，校正后p值小于0.05）相比，PBC患者中DR4显著增多（70例分型中有29例，即41.1%），但与当地样本（129例中有47例，即36.4%）相比无显著差异。PBC患者中，52.9%仅鉴定出一种DR抗原，而国际样本为67.5%，当地样本为49.6%。在以往研究中，与PBC相关性最强的HLA抗原是DR8，但我们的抗血清样本中未包含该抗原。然而，在所筛查的抗原中，未发现HLA与PBC之间存在显著关联。
