Ercilla G, Parés A, Arriaga F, Bruguera M, Castillo R, Rodés J, Vives J
Department of Immunology, Liver Unit, Hospital Clínico y Provincial, Barcelona, Spain.
Tissue Antigens. 1979 Nov;14(5):449-52. doi: 10.1111/j.1399-0039.1979.tb00874.x.
Twenty-one unrelated Caucasian patients with Primary Biliary Cirrhosis were typed for HLA-A, B, C and HLA-DRw antigens. The antigens HLA-Al, HLA-B8 and HLA-DRw3 were found in increased frequency in relation to the control group. When the P values were corrected for the number of antigens tested only the increase of HLA-DRw3 remained significantly different from the control group (P crr. < 0.004). The antigen HLA-DRw3 was carried by 12 out of 21 patients (57.1%) in comparison to 11 out of 74 (14.8%) normal unrelated Caucasian subjects.
对21例原发性胆汁性肝硬化的非亲缘关系白种人患者进行了HLA - A、B、C和HLA - DRw抗原分型。发现HLA - A1、HLA - B8和HLA - DRw3抗原在患者中的出现频率高于对照组。当对所检测抗原的数量进行P值校正后，只有HLA - DRw3的增加与对照组仍存在显著差异（校正P值<0.004）。21例患者中有12例（57.1%）携带HLA - DRw3抗原，而在74例正常非亲缘关系白种人中只有11例（14.8%）携带该抗原。
