Zaniboni A, Marpicati P, Simoncini E, Gorni F, Ferrari V, Raffaglio E, Garattini M P, Marini G
IIIa Medicina, Fondazione Beretta, Spedali Civili, Brescia, Italia.
Anticancer Res. 1987 Jul-Aug;7(4B):813-5.
Twenty-five patients with advanced breast cancer were treated every 28 days with Cisplatin, 30 mg/m2 iv on days 1,3,5; Epirubicin, 40 mg/m2 iv on day 1; Cyclophosphamide, 200mg/m2 iv on days 1,3,5. Partial remission was achieved by 7 patients (33%), all of whom had been untreated with chemotherapy. Overall toxicity was moderate but manageable. Severe haematological toxicity was experienced by 5 patients (20%) with grade III anemia; 2 patients had grade II oral mucositis; 4 had grade II diarrhoea Moderate nausea and vomiting were seen in all patients. Although they are only preliminary, our results suggest that this treatment had considerable activity as first line chemotherapy in advanced breast cancer and deserves further evaluation.
25例晚期乳腺癌患者每28天接受一次治疗，具体用药为：顺铂，第1、3、5天静脉注射30mg/m²；表柔比星，第1天静脉注射40mg/m²；环磷酰胺，第1、3、5天静脉注射200mg/m²。7例患者（33%）实现部分缓解，这些患者均未接受过化疗。总体毒性为中度，但可控制。5例患者（20%）出现严重血液学毒性，为III级贫血；2例患者出现II级口腔黏膜炎；4例患者出现II级腹泻。所有患者均有中度恶心和呕吐症状。尽管这些结果只是初步的，但我们的研究表明，这种治疗作为晚期乳腺癌的一线化疗具有相当的活性，值得进一步评估。
