Fornasiero A, Daniele O, Aversa S M, Ghiotto C, Morandi P, Fiorentino M V
Department of Medical Oncology, Padua General Hospital, Italy.
Chemioterapia. 1987 Aug;6(4):310-2.
The activity of the association of cis-platinum with Adriamycin and cyclophosphamide (CAP), as "rescue" chemotherapy for the treatment of refractory and relapsing advanced breast cancer, is presented. Of 42 evaluable patients, previously treated with chemotherapy +/- hormone therapy, 4 (9.5%) achieved a complete response, 15 (35%) had a partial response (CR + PR = 45%). Major toxicity observed was: nausea and vomiting in 95% of patients and leukopenia in 60%.
本文介绍了顺铂联合阿霉素及环磷酰胺（CAP）作为“挽救性”化疗方案治疗难治性和复发性晚期乳腺癌的活性。42例可评估患者此前接受过化疗及/或激素治疗，其中4例（9.5%）达到完全缓解，15例（35%）部分缓解（完全缓解 + 部分缓解 = 45%）。观察到的主要毒性反应为：95%的患者出现恶心和呕吐，60%的患者出现白细胞减少。
