Vincent-Chong Vui King, Seshadri Mukund
Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Department of Dentistry and Maxillofacial Prosthetics Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Front Oral Health. 2021 Jun;2. doi: 10.3389/froh.2021.689482. Epub 2021 Jun 8.
Head and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that often lead to debilitating changes in appearance, speech, swallowing and respiratory function in patients. It is therefore critical to develop novel targeted treatment strategies that can effectively target multiple components within the tumor microenvironment. In this regard, there has been an increased recognition of the role of neural signaling networks as mediators of disease progression in HNSCC. Here, we summarize the current knowledge on the mechanisms of adrenergic signaling in HNSCC specifically focusing on neurovascular crosstalk and the potential of targeting the adrenergic-angiogenic axis through repurposing of FDA-approved drugs against HNSCC.
头颈部鳞状细胞癌（HNSCC）是局部侵袭性肿瘤，常导致患者外观、言语、吞咽和呼吸功能出现衰弱性变化。因此，开发能够有效靶向肿瘤微环境中多个成分的新型靶向治疗策略至关重要。在这方面，人们越来越认识到神经信号网络作为HNSCC疾病进展介质的作用。在此，我们总结了目前关于HNSCC中肾上腺素能信号传导机制的知识，特别关注神经血管相互作用以及通过重新利用FDA批准的药物靶向肾上腺素能-血管生成轴治疗HNSCC的潜力。
