Rome R M, Koh H, Fortune D, Cauchi M
Oncology Unit, Royal Women's Hospital, Melbourne.
Aust N Z J Obstet Gynaecol. 1987 May;27(2):142-5. doi: 10.1111/j.1479-828x.1987.tb00966.x.
CA125 serum levels were assayed prior to 57 secondary laparotomies for ovarian epithelial tumours. Tumour was present in all 16 patients with an elevated level greater than 35 U/ml but the absence of tumour was incorrectly predicted in 15 of the 33 (45.5%) patients with CA125 levels less than 35 U/ml. For these patients the CA125 level was elevated in 14 of 20 (70%) with tumour greater than 1.5 cm, 1 of 7 (14.3%) with macroscopic tumour less than or equal to 1.5 cm and 1 of 4 (25%) with microscopic tumour. Tumour was resectable to less than or equal to 0.5 cm in 7 of 12 (58.3%) patients with CA125 less than 35 U/ml, 2 of 4 (50%) with CA125 in the range 35-100 U/ml and only 1 of 11 (9.1%) with CA125 greater than 100 U/ml (p less than .05). The CA125 level was elevated in 1 of 13 (7.7%) patients with less than 15 cm3 of tumour compared with 16 of 18 (88.9%) patients with 15 cm3 of tumour or more (p less than .0001). The correlation between the CA125 serum level and the tumour volume was almost statistically significant (r = +0.31, p = .053). The level of CA125 was normal in all 8 patients with mucinous tumours--4 of whom were found to have tumour at secondary surgery.(ABSTRACT TRUNCATED AT 250 WORDS)
对57例卵巢上皮性肿瘤患者进行二次剖腹手术前检测了CA125血清水平。16例CA125水平高于35 U/ml的患者均存在肿瘤，但在33例（45.5%）CA125水平低于35 U/ml的患者中，有15例被错误预测为无肿瘤。对于这些患者，CA125水平在肿瘤大于1.5 cm的20例患者中有14例（70%）升高，在宏观肿瘤小于或等于1.5 cm的7例患者中有1例（14.3%）升高，在微小肿瘤的4例患者中有1例（25%）升高。在CA125低于35 U/ml的12例患者中有7例（58.3%）肿瘤可切除至小于或等于0.5 cm，在CA125在35 - 100 U/ml范围内的4例患者中有2例（50%）可切除至该范围，而在CA125高于100 U/ml的11例患者中只有1例（9.1%）可切除至该范围（p < 0.05）。肿瘤体积小于15 cm³的13例患者中有1例（7.7%）CA125水平升高，而肿瘤体积为15 cm³或更大的18例患者中有16例（88.9%）CA125水平升高（p < 0.0001）。CA125血清水平与肿瘤体积之间的相关性几乎具有统计学意义（r = +0.31，p = 0.053）。8例黏液性肿瘤患者的CA125水平均正常，其中4例在二次手术时发现有肿瘤。（摘要截短于250字）
