Maneschi F, Geraci P, Barreca P V, Palisi F, Adragna F, Napoli M
Dept. of Obstetrics and Gynecology, University of Palermo, Italy.
Gynecol Endocrinol. 1992 Mar;6(1):25-30. doi: 10.3109/09513599209081003.
Estradiol, progesterone, 17-hydroxyprogesterone, androstenedione and CA125 were assayed in 25 women (12 oophorectomized before entering the study) with ovarian carcinoma. The data from patients were ordered according to the presence or absence of the gonads. The patients with ovaries (Group A) showed significantly higher levels of estradiol (p less than 0.01), progesterone (p less than 0.01) and 17-hydroxyprogesterone (p less than 0.01) than controls. This difference was not observed between oophorectomized patients (Group B) and controls. CA125 levels were significantly higher in patients that in controls (p less than 0.001) irrespective of the ovarian status of the patients. Eleven patients were followed during chemotherapy. Significant reductions of estradiol (p less than 0.01) and CA125 (p less than 0.001) levels after three courses of chemotherapy were observed. These data confirm that women with ovarian carcinoma produce an abnormal amount of steroids. Nevertheless, a marked difference between patients with and without ovaries was observed, suggesting that reported data might be biased by the presence of gonadal tissue. Thus the clinical application of steroids as tumor markers in unselected patients is limited.
对25例卵巢癌女性患者（其中12例在进入研究前已行卵巢切除术）检测了雌二醇、孕酮、17 - 羟孕酮、雄烯二酮和CA125。根据有无性腺对患者数据进行排序。有卵巢的患者（A组）与对照组相比，雌二醇（p < 0.01）、孕酮（p < 0.01）和17 - 羟孕酮（p < 0.01）水平显著更高。在已行卵巢切除的患者（B组）和对照组之间未观察到这种差异。无论患者的卵巢状态如何，患者的CA125水平均显著高于对照组（p < 0.001）。11例患者在化疗期间接受随访。观察到三个疗程化疗后雌二醇（p < 0.01）和CA125（p < 0.001）水平显著降低。这些数据证实卵巢癌女性产生异常量的类固醇。然而，观察到有卵巢和无卵巢的患者之间存在明显差异，提示所报道的数据可能因性腺组织的存在而有偏差。因此，在未经过挑选的患者中，类固醇作为肿瘤标志物的临床应用是有限的。
