Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic Health Systems, Mankato, Minnesota, USA.
J Infect Dis. 2022 Feb 15;225(4):598-602. doi: 10.1093/infdis/jiab570.
Breakthrough coronavirus disease 2019 (COVID-19) may occur in fully vaccinated persons.
We assessed the clinical outcomes of breakthrough COVID-19 in fully vaccinated individuals.
In this cohort of 1395 persons (mean age, 54.3 years; 60% female; median body mass index, 30.7) who developed breakthrough COVID- 19, there were 107 (7.7%) who required hospitalization by day 28. Hospitalization was significantly associated with the number of medical comorbidities. Antispike monoclonal antibody treatment was significantly associated with a lower risk of hospitalization (odds ratio, 0.227; 95% confidence interval, 0.128-0.403; P < .001). The number needed to treat (NNT) to prevent 1 hospitalization was 225 among the lowest risk patient group compared with NNT of 4 among those with highest numbers of medical comorbidity.
Monoclonal antibody treatment is associated with reduced hospitalization in vaccinated high-risk persons with mild to moderate COVID-19.
突破性的 2019 冠状病毒病(COVID-19)可能发生在完全接种疫苗的人群中。
我们评估了完全接种疫苗的个体中突破性 COVID-19 的临床结果。
在这组 1395 名(平均年龄 54.3 岁;60%为女性;中位数体重指数 30.7)发生突破性 COVID-19 的人中,有 107 人(7.7%)在第 28 天需要住院治疗。住院治疗与医疗合并症的数量显著相关。抗刺突单克隆抗体治疗与降低住院风险显著相关(比值比,0.227;95%置信区间,0.128-0.403;P<0.001)。与患有最高数量医疗合并症的患者相比,在风险最低的患者组中,预防 1 例住院的需要治疗人数(NNT)为 225,而 NNT 为 4。
在轻度至中度 COVID-19 的接种高风险人群中,单克隆抗体治疗与降低住院率相关。