免疫功能低下儿童艰难梭菌感染的流行病学、诊断和治疗。
Epidemiology, Diagnosis, and Treatment of Clostridioides difficile Infection in Immunocompromised Children.
机构信息
Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
出版信息
J Pediatric Infect Dis Soc. 2021 Nov 17;10(Supplement_3):S46-S51. doi: 10.1093/jpids/piab078.
Abstract
Clostridioides difficile infection is very common in immunocompromised children. Management is confounded by frequent asymptomatic colonization, multiple alternative etiologies for gastrointestinal symptoms, and high rates of relapse. Important considerations include indications for testing, appropriate choice of diagnostic tests, antibiotic therapy for initial and subsequent episodes, and primary and secondary prevention.
摘要
艰难梭菌感染在免疫功能低下的儿童中非常常见。由于频繁的无症状定植、胃肠道症状的多种替代病因以及高复发率，其管理变得复杂。重要的考虑因素包括检测的指征、诊断检测的适当选择、初始和后续发作的抗生素治疗以及一级和二级预防。
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