From the Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN.
Department of Pharmacy, Le Bonheur Children's Hospital, Memphis, TN.
Pediatr Infect Dis J. 2021 Jul 1;40(7):634-636. doi: 10.1097/INF.0000000000003117.
Clostridioides difficile infection guidelines were published in final format on April 1, 2018. Among 4962 and 3545 C. difficile infection cases in children the year before and after publication, oral metronidazole use decreased from 63.0% to 44.3% (P < 0.001) and oral vancomycin use increased from 27.3% to 47.7% (P < 0.001). Quarterly metronidazole utilization decreased postguidelines among 117 institutions, incidence rate ratios 0.86 (95% confidence intervals: 0.78-0.96).
艰难梭菌感染指南于 2018 年 4 月 1 日以最终形式发布。在发布前后的一年中，分别有 4962 例和 3545 例儿童艰难梭菌感染病例，口服甲硝唑的使用率从 63.0%降至 44.3%（P<0.001），口服万古霉素的使用率从 27.3%升至 47.7%（P<0.001）。在 117 家机构中，发布指南后每季度甲硝唑的使用率下降，发病率比值为 0.86（95%置信区间：0.78-0.96）。
